2013 Fiscal Year Final Research Report
Analysis of neuroprotective function of Parkinson's Disease Gene DJ-1
| Project/Area Number |
23790970
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | DJ-1 / パーキンソン病 / PARK7 / 酸化ストレス / 分泌 |
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| Research Abstract |
[Function analysis of DJ-1 secreted under oxidative stress] We found that secreted DJ-1 from astrocytes protected co-cultured neurons against oxidative stress. Furthermore, we found that the amount of secreted DJ-1 mutants found in Familial Parkinson's disease PARK7 was less than DJ-1 wt.
[Function analysis of DJ-1 as protease] We analyzed the biochemical characterization of DJ-1 protease. Futhermore, we identified the recognition sequences for DJ-1 protease and targeted proteins.
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[Journal Article] Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice2013
Author(s)
Yamane, T., Suzui, S., Kitaura, H., Takahashi-Niki K,, Iguchi-Ariga, S.M.M. and Ariga, H.
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Journal Title
PLoS ONE
Volume: 8(11)
Pages: e78374
DOI
Peer Reviewed
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[Journal Article] Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis2012
Author(s)
Yamaguchi S, Yamane T, Takahashi-Niki K, K, Kato I, Niki T, Goldberg MS, Shen J, Ishimoto K, Doi T,Iguchi-Ariga SM,Ariga H
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Journal Title
PLoS One
Volume: 7(5)
Pages: e38144
DOI
Peer Reviewed
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