2012 Fiscal Year Final Research Report
Biomarkers predicting therapeutic effects in patients with spinal and bulbar muscular atrophy (SBMA)
| Project/Area Number |
23790986
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
BANNO Haruhiko 名古屋大学, 高等研究院(医), 特任講師 (40594057)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経変性疾患 / 球脊髄性筋萎縮症 / 運動ニューロン疾患 / 臨床試験 / バイオマーカー / プロテオーム解析 / 分子標的治療 |
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| Research Abstract |
SBMA, also known as Kennedy’s disease, is an adult-onset, hereditarymotor neuron disease characterized by muscle atrophy, weakness and bulbar involvement. Given that SBMA is a slowly progressive disease, extremely long-term clinical trials are likely necessary to verify clinical benefits of disease-modifying therapies. Suitable surrogate endpoints, which reflect the pathogenesis and severity of SBMA, are thus substantial to assess the therapeutic efficacy in drug trials. To this end, appropriate biomarkers should be identified and validated in translational researches. In this research, we analyzed patients’ serum and urine using proteomics approach.
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[Journal Article] Longitudinal changes of outcome measures in spinal and bulbar muscularatrophy2012
Author(s)
Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Mano T, Atsuta N, Oe H, Watanabe H, Tanaka F, Sobue G
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Journal Title
Brain
Volume: 135
Pages: 2838-48
DOI
Peer Reviewed
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