2012 Fiscal Year Final Research Report
Elucidation of development and improvement of leptin resistance
| Project/Area Number |
23791054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
KUSAKABE Toru 京都大学, 医学研究科, 助教 (60452356)
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| Project Period (FY) |
2011 – 2012
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| Keywords | レプチン / レプチン抵抗性 |
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| Research Abstract |
Coadministration of leptin and exenatide significantly reduced food intake and body weight in obese type2 diabetic mice, compared with either monotherapy alone. Moreover, coadministration of leptin and exenatide normalized blood glucose levels accompanied by improvement of insulin sensitivity, restoration of glucose stimulated insulin secretion, normalization of triglyceride contents in non-adipose tissues, improvement of plasma glucagon levels and restoration of pancreatic insulin contents, while not each monotherapy. Pair-feeding experiments indicated that exenatide enhanced the leptin’s effects through independent mechanism of caloric restriction. These findings suggest that coadministration of leptin and exenatide could be a beneficial treatment for obese type2 diabetes by eliciting leptin’s effects.
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[Journal Article] Leptin activates hepatic 5' AMP-Activated Protein Kinase through sympathetic nervous system and α1 adrenergic receptor:A potential mechanism for improvement of fatty liver in lipodystrophy by leptin2012
Author(s)
L. Miyamoto, K. Ebihara, T. Kusakabe, D. Aotani, S. Yamamoto-Kataoka, T. Sakai, M. Aizawa-Abe, Y. Yamamoto, J. Fujikura, T. Hayashi, K. Hosoda, K. Nakao
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Journal Title
J Biol Chem
Volume: 287
Pages: 40441- 40447
DOI
Peer Reviewed
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[Journal Article] Functional Magnetic Resonance Imaging Analysis of Food-Related Brain Activity in Patients with Lipodystrophy Undergoing Leptin Replacement Therapy2012
Author(s)
D. Aotani, K. Ebihara, N. Sawamoto, T. Kusakabe, M. Aizawa-Abe, S. Kataoka, T. Sakai, H. Iogawa, C. Ebihara, J. Fujikura, K. Hosoda, H. Fukuyama, K. Nakao
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Journal Title
J Clin Endocrinol Metab
Volume: 97
Pages: 3663- 3671
DOI
Peer Reviewed
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[Journal Article] Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice2012
Author(s)
T. Kusakabe, K. Ebihara, T. Sakai, L. Miyamoto, D. Aotani, Y. Yamamoto, S. Yamamoto-Kataoka, M. Aizawa-Abe, J. Fujikura, K. Hosoda, K. Nakao 、
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302
Pages: E924-931
DOI
Peer Reviewed
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