2012 Fiscal Year Final Research Report
Demonstration of Hes-1oscillation in progenitors and analysis of its effect on differentiation in hematopoiesis
| Project/Area Number |
23791070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血液腫瘍学 / Hes-1 / 白血病 / 発現振動 |
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| Research Abstract |
We demonstrated ultradian oscillation of Hes-1 expression in single hematopoietic progenitor cells separated from murine fetal liver. Hematopoietic progenitors introduced with MLL-AF9 fusion gene cause leukemia in in vivo model. When progenitors derived from Hes-1 knockout mice were used, the Hes-1-knockout cells with MLL-AF9 caused earlier death than wild-type cells, which indicated that Hes-1 works as tumor suppressor gene in MLL-AF9 leukemia.
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