2012 Fiscal Year Final Research Report
Regulation of autoreactive B cells in an anti-DNA antibody- knock-in mouse model
| Project/Area Number |
23791111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHIFUJI Hajime 京都大学, 大学院・医学研究科臨床免疫学, 助教 (20422975)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 膠原病学 |
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| Research Abstract |
A therapy that inhibits only autoreactive lymphocytes is desirable for the treatment of systemic lupus erythematosus (SLE). We analyzed an SLE model ‘anti-DNA-antibody-knock-in mouse' to know how autoreactive B cells are regulated. The homozygotes' splenic B cells were significantly decreased, and their maturation was inhibited in the bone marrow. Homo's B cells tended to move to the marginal zone in their spleens. Homo's B cells showed low expression levels of IgM/IgD, and were supposed to be regulated by anergy. Further analyses will elucidate the pathophysiology of SLE.
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Research Products
(4 results)
