2014 Fiscal Year Final Research Report
Clinicopathological study of frontotemporal lobar degeneration
| Project/Area Number |
23791346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
KATSUSE Omi 横浜市立大学, 医学部, 講師 (40420674)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 認知症 / 神経変性疾患 |
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| Outline of Final Research Achievements |
We reported 3 cases of Nasu-Hakola disease and a case of concurrent Huntington's disease and neurofibromatosis type 1. These cases had clinical presentation like frontotemporal lobar degeneration (FTLD). And, clinical and pathological features of 66 cases with FTLD were studied. Although FTLD is clinicopathological heterogeneous disorders, our results suggest that there pathological subtypes tend to have particular clinical Symptoms. Further,we pathologically studied the localization of fused in sarcoma (FUS) protein which is one of some proteins leading to FTLD. The results revealed that FUS protein is detecyed in the post-synaptic density.
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| Free Research Field |
認知症
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