2012 Fiscal Year Final Research Report
Etiology elucidation of schizophrenia that focus on oligodendrocyte progenitor cells
| Project/Area Number |
23791362
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TOYOSHIMA Manabu 独立行政法人理化学研究所, 分子精神科学研究チーム, 基礎科学特別研究員 (90582750)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 統合失調症 / NG2(+)細胞 |
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| Research Abstract |
We analyzed change of gene expression and cell counts in NG2 (+) cell by using therapeutic drug-treated NG2DsRed mice and schizophrenia-model NG2DsRed mice. We observed that NG2 (+) cell counts and expression of Rbpj gene changed in the lithium-treated NG2DsRed mice. These results suggest that Lithium controls the proliferation and differentiation of NG2 (+) cells via Notch signaling.
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Research Products
(9 results)
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[Journal Article] A population-specific uncommon variant in GRIN3A associated with schizophrenia.2013
Author(s)
Takata A, Iwayama Y, Fukuo Y, Ikeda M, Okochi T, Maekawa M, Toyota T, Yamada K, Hattori E, Ohnishi T, Toyoshima M, Ujike H, Inada T, Kunugi H, Ozaki N, Nanko S, Nakamura K, Mori N, Kanba S, Iwata N, Kato T, Yoshikawa T.
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Journal Title
Biological Psychiatry
Volume: 73
Pages: 532-539
Peer Reviewed
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