Immunological tolerance of donor-specific transfusioninduced by Indoleamine 2,3-dioxygenase (IDO) positive dendritic cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791488
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: The University of Tokushima
• Principal Investigator: IKEMOTO Tetsuya 徳島大学, 大学院・へルスバイオサイエンス研究部, 助教 (20398019)
• Project Period (FY): 2011 – 2012
• Keywords: Foxp3 / 調節性T細胞 / 免疫寛容

Research Abstract

A possible mechanism of donor-specific tolerance by donor-specific transfusion (DST) is to be induced by donor-derived CD11b+cells due to an expansion of regulatory T cells in recipient, this mechanism is considered that recipient Indoleamine 2,3-dioxygenase positive dendritic cells play an important role

Research Products

• [Journal Article] Changes of Immunological parameters with administration of Japanese Kampo medicine (Juzen-Taihoto/TJ-48) in patients with advanced pancreatic cancer. (2013)
  • Author(s): Ikemoto T, Shimada M, Iwahashi S, et al.
  • Journal Title: Int J Clin Oncol Pages: in press
  • Peer Reviewed
• [Journal Article] Indoleamine 2,3-dioxygenase Affects the Aggressiveness of Intraductal Papillary Mucinous Neoplasms Through Foxp3+CD4+CD25+ T Cells in Peripheral Blood. (2012)
  • Author(s): Ikemoto T, Shimada M, Komatsu M,et al.
  • Journal Title: Pancreas
  • Peer Reviewed
• [Presentation] 各臓器移植における免疫寛容 IFN inducible IDO+形質細胞様樹状細胞による免疫寛容誘導 (2011)
  • Author(s): 池本哲也、島田光生 他
  • Organizer: 第47回日本移植学会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2011-10-04
• [Presentation] The role of donor specific regulatory T cells expanded by interferon-gamma inducible indoleamine 2, 3-dioxygenase (IDO) + plasmacytoid dendritic cell (2011)
  • Author(s): Ikemoto T, et al.
  • Organizer: 12th Congress of the Asian Society of Transplantation
  • Place of Presentation: COEX(韓国)
  • Year and Date: 2011-09-25