2013 Fiscal Year Final Research Report
Functional analysis of BRCA1/BAP1 complex
| Project/Area Number |
23791504
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
NISHIKAWA Hiroyuki 聖マリアンナ医科大学, 医学(系)研究科(研究院), 研究技術員 (90387077)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 癌抑制遺伝子 |
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| Research Abstract |
I went to the identification of proteins that bind to the BAP1 in the cell.
It was possible to identify the interaction factor of 51 types. Histone chaperone protein, the chromatin remodeling association was found as multiple interacting factors and BAP1 in this experiment.
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[Journal Article] A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair2012
Author(s)
Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan AD, Ayoub N, Schiess R, Aebersold R, Nishikawa H, Sedukhina AS, Wada H, Ohta T, Venkitaraman AR.
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Journal Title
Curr Biol
Volume: 22
Pages: 1659-66
Peer Reviewed
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