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2012 Fiscal Year Final Research Report

MicroRNA expression analysis of the gastric cancer peritoneal carcinomatosis

Research Project

  • PDF
Project/Area Number 23791525
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionMie University

Principal Investigator

OKUGAWA Yoshinaga  三重大学, 三重大学, 助教 (30555545)

Project Period (FY) 2011 – 2012
Keywords胃十二指腸外科学
Research Abstract

Establishment of metastasis mechanism contributes greatly to improving prognosis. The aim of this study is to clarify the significance of miRNA / mRNA expression profile in gastric cancer tissues and to clarify the mechanism of peritoneal metastasis in gastric cancer. MiR151-5p expression analysis in cancer tissue and adjascent normal mucosa in gastric cancer patientsdemonstrated that overexpression of miR151-5p was significantly correlated with synchronous peritoneal metastasis and poor prognosis in gastric cancer patients. In vitro analysis,downregulation of miR151-5p suppressed the proliferation and invasive ability in gastric cancer cells. On the other hand, we have demonstrated that brain derived neurotrophic factor / tropomyosin-related kinase B pathway is deeply involved in the formation of peritonealmetastasis in the gastric cancer.

  • Research Products

    (8 results)

All 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Brain-derived neurotrophic factor /tropomyosin -related kinase B pathway in gastric cancer.2013

    • Author(s)
      Okugawa Y, Tanaka K, Inoue Y, Kawamura M, Kawamoto A, Hiro J, Saigusa S, Toiyama Y, Ohi M, Uchida K, Mohri Y, Kusunoki M.
    • Journal Title

      Br J Cancer

      Volume: 108(1) Pages: 121-30

    • Peer Reviewed
  • [Journal Article] Smad interacting protein 1 (SIP1) is associated with peritoneal carcinomatosis in intestinal type gastric cancer.2012

    • Author(s)
      Okugawa Y, Inoue Y, Tanaka K, Kawamura M, Saigusa S, Toiyama Y, Ohi M, Uchida K, Mohri Y, Kusunoki M.
    • Journal Title

      Clin Exp Metastasis

      Volume: (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Clinical significance of serum soluble E-cadherin in colorectal carcinoma.2012

    • Author(s)
      Okugawa Y, Toiyama Y, Inoue Y, Iwata T, Fujikawa H, Saigusa S, Konishi N, Tanaka K, Uchida K, Kusunoki M.
    • Journal Title

      J Surg Res

      Volume: 175(2) Pages: e67-73

    • Peer Reviewed
  • [Journal Article] Clinical significance of Zinc finger E-box Binding homeobox 1 (ZEB1) in human gastric cancer2012

    • Author(s)
      Okugawa Y, Toiyama Y, Tanaka K, Matsusita K, Fujikawa H, Saigusa S, Ohi M, Inoue Y, Mohri Y, Uchida K, Kusunoki M.
    • Journal Title

      J Surg Oncol

      Volume: 106(3) Pages: 280-5

    • Peer Reviewed
  • [Journal Article] CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer2012

    • Author(s)
      Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M
    • Journal Title

      Eur J Cancer

      Volume: 48(14) Pages: 2244-51

    • Peer Reviewed
  • [Journal Article] Intravital dual-colored visualization of colorectal liver metastasis in living mice using two photon laser scanning microscopy.2012

    • Author(s)
      Tanaka K, Morimoto Y, Toiyama Y, Okugawa Y, Inoue Y, Uchida K, Kimura K, Mizoguchi A, Kusunoki M.
    • Journal Title

      Microsc Res Tech

      Volume: 75(3) Pages: 307-15

    • Peer Reviewed
  • [Presentation] Brain derived neurotrophic factor/Tropomyosin-related kinase B (TrkB) axis caused peritoneal dissemination via anoikis resistant in gastric cancer.2012

    • Author(s)
      奥川喜永 ほか
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
  • [Presentation] 胃癌組織における miR151-5p 発現の臨床病理学的意義2012

    • Author(s)
      奥川喜永 ほか
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Year and Date
      2012-07-20

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Published: 2014-09-25  

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