mechanism of bile duct carcinogenesis using rat model of pancreaticobiliary maljunction

2013 Fiscal Year Final Research Report

• Project/Area Number: 23791537
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: The University of Tokushima
• Principal Investigator: YAMADA Shinichiro 徳島大学, 病院, 医員 (30579884)
• Project Period (FY): 2012 – 2013
• Keywords: 膵 / 胆管合流異常 / adenoma-carcinoma sequence / 胆道癌

Research Abstract

In pancreaticobiliary maljunction, reflux of pancreatic juice causes many conditions including inflammation, and may be relate to carcinogenesis. However, mechanism is not well known. This time, we administered DBTC torats and made the model of pancreaticobiliary maljunction. Single dose of 8mg/kg DBTC caused biliary stasis and papillary growth of epithelium, and we confirmed high expression of Ki-67, COX2 and HDAC by immunohistochemistry. However, papillary growth was recovered 4 weeks after administration. As Rats died by frequent dose of DBTC and we could not observe in long time, we try to make mouse model of pancreaticobiliary maljunction by surgical technique.

Research Products

• [Journal Article] Surgical results of pancreatoduodenectomy in elderly patients (2012)
  • Author(s): Yamada S, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Kanamoto M, Hanaoka J, Iwahashi S, Saitoh Y.
  • Journal Title: Surg Today Volume: 42(9) Pages: 857-862
  • Peer Reviewed
• [Presentation] 膵胆管合流異常症におけるepigenetic/genetic修飾を介した胆道癌発癌機構に関する検討. (2012)
  • Author(s): 森 大樹. 他14名
  • Organizer: 第50回 日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 20121025-27
• [Presentation] Risk of carcinogenesis in patients with pancreaticobiliary maljunction through both epigenetic and genetic regulation. (2012)
  • Author(s): 森 大樹.山田 眞一郎
  • Organizer: 第71回 日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 20120919-21
• [Presentation] 膵・胆管合流異常症の胆道上皮は発癌ポテンシャルを有する (2012)
  • Author(s): 森大 樹,山田 眞一郎
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 20120412-14
• [Presentation] 胆嚢摘出後に胆管癌を発症した胆管非拡張型膵・胆管合流異常の2症例についての検討. (2012)
  • Author(s): 山田 眞一郎. 他10名.
  • Organizer: 第35回 日本膵・胆管合流異常研究会
  • Place of Presentation: 東京海運クラブ(東京都)
  • Year and Date: 2012-09-08
• [Presentation] 膵・胆管合流異常症における胆道癌発癌機構の解明 (2012)
  • Author(s): 山田 眞一郎, 他15名.
  • Organizer: 第97回 日本消化器病学会四国支部例会
  • Place of Presentation: あわぎんホール(徳島県)
  • Year and Date: 2012-06-30