2012 Fiscal Year Final Research Report

Study of postoperative portal venous thrombosis after splenectomy in cirrhotic patients and its therapeutic implication

Research Project

Project/Area Number	23791546
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	Kyushu University
Principal Investigator	KINJYO Nao 九州大学, 大学病院, 特任助教 (00507791)
Project Period (FY)	2011 – 2012
Keywords	脾門脈外科学
Research Abstract	The aim of study is to elucidate the mechanism of portal venous thrombosis (PVT) after splenectomy in cirrhotic patients. Preoperative study showed that prothrombin time was more prolonged in PVT group than in non PVT group (p=0.0593), and value of antithrombin III was lower in PVT group (p=0.0054). In non PVT group, value of antithrombin III was recovered in a few days after splenectomy, however recovery of antithrombin III was delayed in PVT group after splenectomy and value of antithombin III was significantly lower in PVT group on 7thpostoperative day (p<0.05) than in non PVT group. It is supposed that hypercoagulopathy might be one of causes of PVT after splenectomy due to delayed functional recovery of liver.

(3 results)