2012 Fiscal Year Final Research Report
Development of a method of enhancing antitumor drug delivery byextracellular environment control
Project/Area Number |
23791634
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Mie University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Keywords | 骨・軟部腫瘍学 |
Research Abstract |
The results of this study showed that osteosarcoma, lung cancer and gastric cancer cells which exposed to the complex tumor micro-environment (i.e. high hydrostaticpressure, hypoxic, acidic and low nutrition) controlled their own cell growth and invasiveness and metastasis ability to survie in such severe tumor micro-environmental condition. On the other hand, the release of various cytokines for survive can be integrated to amplify acridine orangewhich is a photosensitizer for malignant tumors, and the contol of micro-tumor environmentenhance the cytotoxic effects by photodynamic therapy.
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Research Products
(19 results)
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[Journal Article] Translational research of photodynamic therapy with acridine orange which targets cancer acidity2012
Author(s)
Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y
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Journal Title
Curr Pharm Des
Volume: 18(10)
Pages: 1414-20
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[Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma2011
Author(s)
Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A
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Journal Title
Anticancer Res.
Volume: 31(12)
Pages: 4163-8
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