2013 Fiscal Year Final Research Report
Effects of an oral pre-administered beta-blocker on cardiopulmonary resuscitation in various cardiac arrests
| Project/Area Number |
23791690
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | β遮断薬 |
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| Research Abstract |
The present studies were performed to evaluate effects of a beta-blocker on cardiac arrests induced by severe hemorrhagic shock and airway obstruction in rats, and on endotoxic shock induced by endotoxin, and on septic shock induced by cecal ligation and punctures in rats. (1) Administration of a beta-blocker on cardiac arrests induced by severe hemorrhagic shock deteriorated prognosis. (2) Administration of a beta-blocker on cardiac arrests induced by airway obstruction in rats improved recovery rate from cardiac arrests. (3) Administration of a beta-blocker on endotoxic shock induced by endotoxin deteriorated prognosis. (4) Administration of a beta-blocker on septic shock induced by cecal ligation and punctures in rats gave no influences on motality.
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