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2013 Fiscal Year Final Research Report

Efffects of D-serine on neurophathic pain

Research Project

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Project/Area Number 23791729
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTokai University

Principal Investigator

ITO Miho  東海大学, 医学部, 助教 (10366073)

Project Period (FY) 2011 – 2013
Keywords神経因性疼痛 / D-セリン / セリンラセマーゼ / Dアミノ酸酸化酵素
Research Abstract

Tail flick or formalin test demonstreated that D-amino acid deficient mice decreased pain threshold. The expressin of mRNA and protein of serine racemase and D-amino acid oxidase increased in forebrain (striatum, hippocampus, cortex) and spinal cord of neuropathic pain model (SNL model). The levels of D-serine increased in forebrain and spinal cord in SNL model. These results demonstrated that elevated D-serine level in SNL model developing neuropathic pain could at least in part be involeved in the activation of NMDA receptor via glycine site.

  • Research Products

    (3 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain2014

    • Author(s)
      Ito M, Yoshikawa M, Ito K, Matsuda M, Jin X.L., Takahashi S, Kobayashi H, Suzuki T
    • Journal Title

      J. Anesthesia

      Volume: 28(2) Pages: 228-234

    • Peer Reviewed
  • [Journal Article] Increase in antinociceptive effect of [Leu5]enkephalin after intrathecal administration of mixture of three peptidase inhibitors2013

    • Author(s)
      Miura, M, Yoshikawa M, Watanabe M, Takahashi S, Ajimi J, Ito K, Ito M, Kawaguchi M, Kobayashi H, Suzuki T
    • Journal Title

      Tokai J Exp Clin Med

      Volume: 38 (2) Pages: 62-70

    • Peer Reviewed
  • [Presentation] 外傷性三叉神経痛第1枝の神経障害性疼痛に対して,C2神経節ブロックが奏功した1症例2013

    • Author(s)
      津田真如,安心院純子,山崎一,伊藤美保,益田律子,鈴木利保
    • Organizer
      第12回神奈川痛みの研究会
    • Place of Presentation
      横浜シンポジア(神奈川)
    • Year and Date
      2013-10-05

URL: 

Published: 2015-06-25  

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