2012 Fiscal Year Final Research Report
Cell-to-cell communication via exosome transfer in endometrial cancer
| Project/Area Number |
23791819
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | 独立行政法人国立がん研究センター (2012)
Kanazawa University (2011) |
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Principal Investigator |
MAIDA Yoshiko 独立行政法人国立がん研究センター, 研究所, ユニット長 (20397219)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 子宮内膜癌 / exosome / microRNA |
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| Research Abstract |
Exosomes are small membrane vesicles containing various RNAs. Recent evidence suggests that human cells communicate with each other by exchanging exosomes. We found that endometrial cancer cells transmit gene regulatory small RNAs to endometrial fibroblasts using exosomes as vehicles. The results indicate a novel cell-to-cell communication between cancer cells and stromal cells via exosome transfer.
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