2013 Fiscal Year Final Research Report
Involvement of neuropeptide to the stress-related inner ear diseases
| Project/Area Number |
23791891
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
IDA-ETO Michiru (伊田 みちる) 三重大学, 医学(系)研究科(研究院), 助教 (80393148)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | ストレス / 内耳 / 神経ペプチド / ラット |
|---|
| Research Abstract |
Inner ear disease such as sudden deafness and Meniere disease may be caused by stress. Manserin is distributed in the neuroendocrine system and its expression in the adrenal gland is stress dependent. Recently, I found the localization of manserin in the rat inner ear. In this study, I investigated the relationship between manserin and stress condition.
Manserin localized at the neuronal terminals of the organ of Corti and spiral ganglion in the inner ear, cochlear nucleus in the medulla oblongata, and lateral superior olivary nucleus in the pons. Manserin immunoreactivity in the type II spiral ganglion cells was decreased by the stress. These results suggest that manserin may be involved in the regulation of auditory pathway under the stress condition.
|
Research Products
(6 results)
