2012 Fiscal Year Final Research Report
Study of artificial cornea transplantation by using collagen cross-linking for corneal thinning disease
| Project/Area Number |
23791970
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIYAI Takashi 東京大学, 医学部附属病院, 助教 (40599007)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 角膜 / コラーゲン |
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| Research Abstract |
We studied changes of corneal property by UV-A collagen crosslinking, in order to develop artificial corneal stroma as a final goal. We attempted to establish a rating system using a rheometer, but reproducibility was insufficient. In a rabbit study of angiogenesis by suture neovascularization model, there was no difference between cross-linked eye and control. In a rabbit study to compare epithelium-on crosslinking with epithelium-off by anterior segment OCT, we found the level of demarcation line was shallow in epithelium-on eyes.
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