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2012 Fiscal Year Final Research Report

Research for the molecular mechanism of Behcet's disease

Research Project

  • PDF
Project/Area Number 23791997
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionYokohama City University

Principal Investigator

KAWAGOE Tatsukata  横浜市立大学, 医学部, 助教 (20564800)

Co-Investigator(Renkei-kenkyūsha) MIZUKI Nobuhisa  横浜市立大学, 医学研究科, 教授 (90336579)
OHTSUKA Masato  東海大学, 医学部, 講師 (90372945)
Project Period (FY) 2011 – 2012
Keywords眼免疫学
Research Abstract

The progress and achievements of research on the new HLA-B51 transgenic mouse model of Behcet’s disease: The exact cause of Behcet’s disease is still unclear. However, it is well known that there is high incidence of HLA-B51 in patients with Behcet’s disease. In this study, we generated new transgenic mice to elucidate the function of HLA-B51 in Behcet’s disease.

  • Research Products

    (10 results)

All 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (1 results)

  • [Journal Article] Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP12013

    • Author(s)
      Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, Gul A, Remmers EF, Kastner DL
    • Journal Title

      Nat Genet

      Volume: 45(2) Pages: 202-7

    • Peer Reviewed
  • [Journal Article] piggyBac-mediated generation of stable transfectants with surface human leukocyte antigen expression from a small number of cells2013

    • Author(s)
      Miura H, Inoko H, Inoue I, Okada Y, Tanaka M, Sato M, Ohtsuka M
    • Journal Title

      Anal Biochem

      Volume: 437(1) Pages: 29-31

    • Peer Reviewed
  • [Journal Article] Infliximab monotherapy versus infliximab and colchicine combination therapy in patients with Behcet's disease2012

    • Author(s)
      Takeuchi M, Asukata Y, Kawagoe T, Ito N, Nishide T, Mizuki N
    • Journal Title

      Ocul Immunol Inflamm

      Volume: 20(3) Pages: 193-7

    • Peer Reviewed
  • [Journal Article] PITT: pronuclear injection-based targeted transgenesis, a reliable transgene expression method in mice2012

    • Author(s)
      Ohtsuka M, Miura H, Sato M, Kimura M, Inoko H, Gurumurthy CB
    • Journal Title

      Exp Anim

      Volume: 61(5) Pages: 489-502

    • Peer Reviewed
  • [Journal Article] Development of a technique for efficient gene transfer to antral follicular cells in the mouse ovary2012

    • Author(s)
      Sato M, Akasaka E, Saitoh I, Ohtsuka M, Watanabe S
    • Journal Title

      Syst Biol Reprod Med

      Volume: 58(3) Pages: 136-41

    • Peer Reviewed
  • [Journal Article] Targeted transgenesis through pronuclear injection of improved vectors into in vitro fertilized eggs2012

    • Author(s)
      Ohtsuka M, Miura H, Nakaoka H, Kimura M, Sato M, Inoko H
    • Journal Title

      Transgenic Res

      Volume: 21(1) Pages: 225-6

    • Peer Reviewed
  • [Journal Article] Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population2012

    • Author(s)
      Horie Y, Meguro A, Kitaichi N, Lee EB, Kanda A, Noda K, Song YW, Park KS, Namba K, Ota M, Inoko H, Mizuki N, Ishida S, Ohno S
    • Journal Title

      Rheumatology (Oxford)

      Volume: 51(6) Pages: 983-6

    • Peer Reviewed
  • [Journal Article] Clinical Course before and after Cataract and Glaucoma Surgery under Systemic Infliximab Therapy in Patients with Behcet's Disease2011

    • Author(s)
      Nishida T, Shibuya E, Asukata Y, Nakamura S, Ishihara M, Hayashi K, Takeno M, Ishigatsubo Y, Mizuki N
    • Journal Title

      Case Rep Ophthalmol

      Volume: 2(2) Pages: 189-92

    • Peer Reviewed
  • [Journal Article] Association analysis of Toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese patients2011

    • Author(s)
      Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Hum Immunol

      Volume: 72(3) Pages: 269-72

    • Peer Reviewed
  • [Presentation] ベーチェット病疾患関連遺伝子HLA-B51の機能解析2013

    • Author(s)
      河越龍方
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京国際フォーラム (東京都)
    • Year and Date
      2013-04-04

URL: 

Published: 2014-09-25  

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