2012 Fiscal Year Final Research Report
Analysis of the functions of Cbfb, a cotranscription factor of Runxfamily proteins, in skeletal and tooth development.
| Project/Area Number |
23792108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | Cbfb / Runx2 / 骨芽細胞 / 軟骨細胞 / 骨形成 / コンディショナルノックアイトマウス / Dermo1 |
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| Research Abstract |
Cbfb is a cotranscription factor of Runx proteins. It forms a heterodimer with Runx family proteins and binds to DNA. To elucidate the function of Cbfb in skeletal development, we generated conditional knockout mice, in which Cbfb was deleted in mesenchymal cells in whole body. In Cbfb conditional knockout mice, bone formation and chondrocyte differentiation were retarded, indicating that Cbfb plays an important role in skeletal development.
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