2012 Fiscal Year Final Research Report
Elucidation of the effect of the volatile anesthetics in the mechanism of the cell death by the myocardial ischemia-reperfusion injury
| Project/Area Number |
23792396
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 虚血性心疾患 / 心筋保護 / 揮発性麻酔薬 / オートファジー / アポトーシス |
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| Research Abstract |
Sevoflurane postconditioning reduced the infarct size by induction of autophagy. expression of LC3-II and the ratio of LC3-II/I were significantly increased in sevoflurane groups. Administration of 3-MA abolished these cardioprotective effects of sevofluranegroups. Expression of LC3-II and the ratio of LC3-II/I were significantly increased in POST and POST-L. Administration of 3-MA abolished these cardioprotective effects of POST. Sevoflurane postconditioning induces autophagy which plays an important role in cardioprotection against IR.
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