2012 Fiscal Year Final Research Report
Analysis of Th17 cells migration inperiodontally diseased tissues.
| Project/Area Number |
23792479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HOSOKAWA Yoshitaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90346601)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯周炎 / Th17 / ケモカイン / 線維芽細胞 |
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| Research Abstract |
We examined the effect of IL-17A or TWEAK on CCL20 production from IL-1・-stimulated human gingival fibroblasts (HGFs) in this study. We found that IL-17A or TWEAK could synergistically enhance CCL20 production from IL-1・-stimulated HGFs. Therefore, IL-17A and TWEAK are involved in Th17 cells migration in periodontally diseased tissues to induce CCL20 production in HGFs. These results might explain that IL-17A and TWEAK are related to the exacerbation of periodontal disease.
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