2013 Fiscal Year Final Research Report

A role of serum amyloid A in atherosclerosis onset.

Research Project

Project/Area Number	23792491
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Periodontal dentistry
Research Institution	Aichi Gakuin University (2012-2013) Matsumoto Dental University (2011)
Principal Investigator	NISHIDA Eisaku 愛知学院大学, 歯学部, 非常勤講師 (10512519)
Project Period (FY)	2011 – 2012
Keywords	歯周病 / 動脈硬化症 / 血管内皮細胞 / 単球遊走因子 / 単球接着因子
Research Abstract	Periodontitis is a local inflammatory disease, and it has been reported that this disease might affect the onset of atherosclerosis. Recently, it has been reported that the injection of IL-6 to the periodontal tissue increased mRNA level in the liver and the protein level in the peripheral blood of serum amyloid A (SAA) in C57BL/6J mice before. SAA is an acute phase protein that affects for the systemic inflammation. Therefore, we tried to examine whether SAA could be a marker of atherosclerogenesis in vitro (human aortic endothelial cells: HAEC) or not. After the induction of SAA protein in HAEC, adhesion molecules were expressed significantly. So, a state of the high concentration SAA presence to continue in peripheral blood was suggested the possibility of developing atherosclerosis.

(4 results)