Effects of remote ischemic preconditioning on cardiac sympathetic nerve and elucidation of cardioprotection mechanism

2012 Fiscal Year Final Research Report

• Project/Area Number: 23800078
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Morinomiya University of Medical Sciences (2012); National Cardiovascular Center Research Institute (2011)
• Principal Investigator: UEDA Shinya 森ノ宮医療大学, 保健医療学部, 助教 (40616926)
• Research Collaborator: SHISHIDO Toshiaki 国立循環器病研究センター, 研究企画調整室, 室長 (60300977) ; AKIYAMA Tsuyoshi 国立循環器病研究センター, 心臓生理機能部, 室長 (70202554)
• Project Period (FY): 2011 – 2012
• Keywords: 遠隔虚血プレコンディショニング(RIPC) / 心臓自律神経 / 心臓マイクロダイア リシス法 / エピネフリン / ノルエピネフリン

Research Abstract

In the present study, we examined the effects of remote ischemic preconditioning (RIPC) on myocardial interstitial norepinephrine (NE) and epinephrine (Epi) levels in the rabbit left ventricle in vivo using microdialysis. As a result, the increase in dialysate NE levels until 30 min of coronary occlusion were significantly enhanced by RIPC. In addition, the suppression of dialysate NE levels during coronary artery occlusion by RIPC do not act so much cardiac sympathetic nerve function changing as other mechanism. Further study is required to elucidate the interplay between neural and humoral pathways underlyingcardioprotection by RIPC.