Analysis and risk assessment of intestinal inflammation induced by food-containing nanoparticles.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23890082
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Mie University
• Principal Investigator: OIKAWA Saeko (TADA Saeko) 三重大学, 地域イノベーション学研究科, 特任助教 (90610585)
• Project Period (FY): 2011 – 2012
• Keywords: ナノ粒子 / 二酸化チタン / 酸化亜鉛 / 炎症

Research Abstract

The present study investigated the cytotoxicity, production of reactive oxygen species (ROS) and inflammatory cytokine induced by nano-TiO2 and nano-ZnO particles using human monocytic leukemia cells (THP-1) and human colon cancer cells (Caco-2). The viability of THP-1 macrophages exposed to nano-ZnO was lower than that to nano-TiO2 THP-1. The production of ROS and IL-1βshowed a tendency to be increased by nano-TiO2 particles. This study indicated that nano-TiO2 particles may induce inflammation in THP-1 macrophages through production of ROS and IL-1β, and nano- ZnO particles were suggested to be more toxic to THP-1 macrophages than nano-TiO_2 .

Research Products

• [Journal Article] Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome (2013)
  • Author(s): Yamaguchi T, Kitamori K, Ichihara G, Suzuki Y, Ochiai M, Yamada Y, Tada-Oikawa S, Tsuchikura S, Yamori Y, Ichihara S
  • Journal Title: Clinical and Experimental Pharmacology and Physiology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat (2012)
  • Author(s): Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S
  • Journal Title: Nutrition & Metabolism (Lond) Volume: 9巻1号 Pages: 87-97
  • DOI: DOI:10.1186/1743-7075-9-87
  • Peer Reviewed
• [Presentation] ナノ酸化亜鉛によるマクロファージの変性LDL取り込み作用への影響 (2013)
  • Author(s): 及川(多田)佐枝子、鈴木悠加、出岡淑、市原学、市原佐保子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2013-03-25
• [Presentation] ナノ酸化亜鉛による血管内皮障害への影響 (2013)
  • Author(s): 鈴木悠加、及川(多田)佐枝子、出岡淑、市原学、市原佐保子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2013-03-25
• [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響 (2013)
  • Author(s): 呉〓〓、市原学、及川(多田)佐枝子、鈴木悠加、常杰、橋本直純、長谷川好規、ガバザコリナ、ガバザエステバン、市原佐保子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2013-03-25
• [Presentation] Zinc oxide particles induced migration of monocytes and increased macrophage cholesterol uptake (2013)
  • Author(s): Yuka Suzuki, Saeko Tada-Oikawa, Gaku Ichihara, Sahoko Ichihara
  • Organizer: 52th Annual Meeting SOCIETY OF TOXICOLOGY
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2013-03-13
• [Presentation] ナノ酸化亜鉛による単球遊走作用とマクロファージのコレステロール取り込み作用への影響 (2013)
  • Author(s): 鈴木悠加、及川(多田)佐枝子、出岡淑、市原学、市原佐保子
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: 筑波
  • Year and Date: 2013-02-01
• [Presentation] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish (2013)
  • Author(s): 常杰、市原学、及川(多田)佐枝子、島田康人、田中利男、市原佐保子
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: 筑波
  • Year and Date: 2013-02-01
• [Presentation] Dispersion method for safety research on manufactured nanomaterials (2012)
  • Author(s): Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
  • Organizer: 第40回産業中毒・生物学的モニタリング研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-16
• [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells (2012)
  • Author(s): Saeko Tada-Oikawa, Masayuki Yabata, Kiyora Izuoka, Jie Chang, Yuka Ota, Wenting Wu, Sahoko Ichihara, Gake Ichihara
  • Organizer: International Congress on Safety of Engineered Nanoparticles and Nanotechnologies
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2012-10-29
• [Presentation] Dispersion Method for Safety Researches on Manufactured Nanomaterials (2012)
  • Author(s): Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
  • Organizer: International Union of Materials Research societies-International Union of Materials Research societies-International Conference on Electronic Materials 2012
  • Place of Presentation: Yokohama
  • Year and Date: 2012-09-26
• [Presentation] Cytotoxicity induced by nano-sized titanium dioxide in human monocytic leukemia cells (THP-1) (2012)
  • Author(s): Saeko Tada-Oikawa, Sahoko Ichihara,, Kiyora Izuoka,, Masayuki Yabata, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
  • Organizer: International Union of Materials Research societies-International Conference on Electronic Materials 2012
  • Place of Presentation: Yokohama
  • Year and Date: 2012-09-24
• [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells (2012)
  • Author(s): Sahoko Ichihara, Saeko Tada-Oikawa, Masayuki Yabata, Kiyora Izuoka, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
  • Organizer: The 6th International Conference on Nanotoxicology
  • Place of Presentation: Beijing, China
  • Year and Date: 2012-09-05
• [Presentation] Dispersion method for safety research on manufactured nanomaterials (2012)
  • Author(s): Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
  • Organizer: The 6th International Conference on Nanotoxicology
  • Place of Presentation: Beijing, China
  • Year and Date: 2012-09-05
• [Presentation] Dispersion method for in vivo safety reseaches on manufactured nanomaterials (2012)
  • Author(s): Wenting Wu, Sahoko Ichihara, Saeko Tada-Oikawa, Jie Chang, Gaku Ichihara
  • Organizer: The 6th International Congress of Asia Society of Toxicology
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2012-07-20
• [Presentation] Oxidative modification leads to the left ventricular dysfunction in cardiomyopathy (2012)
  • Author(s): Sahoko Ichihara, Jie Chang, Saeko Tada-Oikawa, Chisa Ando, Kentaro Kuzuya, Gaku Ichihara, Shinji Oikawa
  • Organizer: The 49th Congress of the European Societies of Toxicology
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2012-06-19
• [Presentation] 二酸化チタンナノ粒子による細胞毒性作用および炎症反応誘導作用の解析 (2012)
  • Author(s): 及川(多田)佐枝子、呉〓〓、市原学 、常杰 、矢端将行 、及川伸二、市原佐保子
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-05-31
• [Presentation] 工業ナノマテリアル安全性研究のための分散法 (2012)
  • Author(s): 呉〓〓、市原佐保子、常杰、及川(多田)佐枝子、太田有香、矢端将行、市原学
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-05-31