Role of interferon regulatory factor(IRF) family transcription factor in microglial activation and neuropathic pain.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23890148
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pain science
• Research Institution: Kyushu University
• Principal Investigator: MASUDA Takahiro 九州大学, 薬学研究院, 特任助教 (80615287)
• Project Period (FY): 2011 – 2012
• Keywords: ミクログリア / 神経障害性疼痛 / IRF / 転写因子 / 中枢性疾患 / P2X4受容体

Research Abstract

We identify the interferon regulatory factor (IRF) member IRF8-IRF5 axis as a critical transcriptional regulator of microglia involved in converting into a P2X4R^hireactive phenotype, which drives neuropathic pain following peripheral nerve injury.

Research Products

• [Journal Article] Microglial regulation of neuropathic pain (2013)
  • Author(s): Tsuda M Masuda T, Tozaki-Saitoh H, Inoue K
  • Journal Title: Journal of Pharmacological Sciences Volume: 121 Pages: 89-94
  • DOI: DOI:10.1254/jphs.12R14CP
  • Peer Reviewed
• [Journal Article] IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype (2012)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Ozato K, Tamura T, Inoue K
  • Journal Title: Cell Reports Volume: 1 Pages: 334-40
  • DOI: DOI:10.1016/j.celrep.2012.02.014
  • Peer Reviewed
• [Presentation] IRF8-IRF5軸は神経障害性疼痛発現を担うP2X4受容体高発現ミクログリアを誘導する (2013)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Iwamoto S, Nishiyama A, Nishimoto N, Tozaki-Saitoh H, Tamura T, Inoue K
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 20130321-23
• [Presentation] IRF8 is a critical transcription factor required for transforming microglia into a reactive phenotype after nerve injury (2012)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Ozato K, Tamura T, Inoue K
  • Organizer: Neuroscience2012
  • Place of Presentation: ニューオリンズ(アメリカ)
  • Year and Date: 20121013-17
• [Presentation] IRF8 transcription factor directs microglia to be a hyperactive phenotype driving neuropathic pain (2011)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Tamura T, Inoue K
  • Organizer: EuroGlia2011
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2011-09-17
• [Remarks]
  • URL: http://yakkou.phar.kyushu-u.ac.jp/