2012 Fiscal Year Final Research Report
Ultrasonic assessment of articular cartilage using contrast medium
| Project/Area Number |
23890234
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Konan Women's University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 関節軟骨 / 超音波 / 造影剤 |
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| Research Abstract |
We have developed the ultrasonic evaluation system for articular cartilage. However this system could detect degeneration of cartilage surface, but could not detect biomechanical properties of all layers of articular cartilage. We investigated the effectiveness of ultrasonic contrast medium for the evaluation system of articular cartilage. The reflex echogram form articular cartilage was shown as A-mode echogram. The peak-peak value was used as a quantitative index of articualr cartilage. Cartialge sample was immersed into contrast mediul for 10 minutes and after that, the sample was immersed in saline and analyzed by the ultrasonic evaluation system.The maximum peak-peak value of samples with contrast medium was 5.3 to 9.8 times higher than the sample without contrast medium. The peak -peak value of sample with contrast medium show the maximum within 2 minutes and decreased as the duration of saline immersion increased. Our finding indicated that ultrasound analysis using contrast medium can predict the biomechanical behavior of articular cartilage.
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[Journal Article] Feasibility and limitations of the round robin test for assessment of in vitro chondrogenesis evaluation protocol in a tissue-engineered medical product2012
Author(s)
Yokoi M, Hattori K, Narikawa K, Ohgushi H, Tadokoro M, Hoshi K, Takato T, Myoui A, Nanno K, Kato Y, Kanawa M, Sugawara K, Kobo T, Ushida T
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Journal Title
Journal of Tissue Engineering and Regenerative Medicine
Volume: 6巻
Pages: 550-558
Peer Reviewed
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