Molecular-anatomical research on multi-modal regulation of synaptic transmission in higher brain regions

2016 Fiscal Year Annual Research Report

• Project/Area Number: 24220007
• Research Institution: Hokkaido University
• Principal Investigator: 渡辺 雅彦 北海道大学, 医学研究科, 教授 (70210945)
• Co-Investigator(Kenkyū-buntansha): 崎村 建司 新潟大学, 脳研究所, 教授 (40162325)
• Project Period (FY): 2012-05-31 – 2017-03-31
• Keywords: シナプス / 情報伝達 / AMPA受容体 / 海馬 / 線条体

Outline of Annual Research Achievements

情報処理が高度に発達した高次脳領域の中心的ニューロンは、莫大な数の神経入力を、シナプスを介した配線伝達により受け取っている。個々のシナプス伝達の重み（比重）は、入力選択的および標的選択的に異なるように設定され、さらにそれぞれのシナプス伝達効率は活動依存的および状況依存的に変化する。本研究は、シナプス伝達の入力依存性、標的依存性、状況依存性の各階層に焦点を当て、その制御機構と機能的意義を分子形態学的視点から解明することが目的である。平成２８年度は、線条体中型有棘細胞におけるAMPA受容体の発現制御を中心に解析を行なった。
線条体は大脳皮質や視床からの興奮性入力を統合し、直接路と間接路の相反的な出力経路を通して運動や認知機能を制御している。直接路と間接路を構成する中型有棘細胞において大脳皮質から投射するVGluT1陽性シナプスと視床から投射するVGluT2陽性シナプスの合計4種類のシナプスにおけるAMPA受容体の発現密度を高感度包埋後免疫電顕法で解析した。その結果、いずれのシナプスにおいてもほぼ同じレベルの発現密度であることが判明した。この観察結果は、グルタミン酸伝達において少数の強いシナプスと多数の弱いシナプスからなる小脳、海馬、大脳皮質のシナプス構成とは異なり、線条体では一様な強さのシナプスから成り立っているという特徴を示している。これは、線条体におけるアセチルコリンやドパミンを介した神経修飾が効率よく出力に反映させるための分子解剖学的基盤と考えられる。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Preprotachykinin A (PPTA) is expressed by a distinct population of excitatory neurons in the mouse superficial spinal dorsal including cells that respond to noxious and pruritic stimuli. (2017)
  • Author(s): Gutierrez-Mecinas M, Bell AM, Marin A, Taylor R, Boyle K, Furuta T, Watanabe M, Polgár E, Todd AJ
  • Journal Title: Pain Volume: 158 Pages: 440-456
  • DOI: 10.1097/j.pain.0000000000000778.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The cellular and synaptic architecture of the mechanosensory dorsal horn. (2017)
  • Author(s): Abraira VE, EmKuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O’Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD
  • Journal Title: Cell Volume: 168 Pages: 295-310
  • DOI: 10.1016/j.cell.2016.12.010.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity. (2017)
  • Author(s): Natsubori A, Tsustui-Kimura I, Nishida H, Bouchekioua Y, Sekiya H, Uchigashima M, Watanabe M, de Kerchove d'Exaerde A, Mimura M, Takata N, Tanaka T
  • Journal Title: J Neurosci Volume: 37 Pages: 2723-2733
  • DOI: 10.1523/JNEUROSCI.3377-16.2017.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation. (2017)
  • Author(s): Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF
  • Journal Title: Nat Commun Volume: 8 Pages: 14304
  • DOI: 10.1038/ncomms14304.
  • Peer Reviewed / Open Access
• [Journal Article] The ascending median raphe projections are mainly glutamatergic in the mouse forebrain. (2016)
  • Author(s): Szonyi A, Mayer MI, Cserép C, Takács VT, Watanabe M, Freund TF, Nyiri G
  • Journal Title: Brain Struct Funct, Volume: 221 Pages: 735-751
  • DOI: 10.1007/s00429-014-0935-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phospho-proteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. (2016)
  • Author(s): Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K
  • Journal Title: Neuron Volume: 89 Pages: 550-565
  • DOI: 10.1016/j.neuron.2015.12.019
  • Peer Reviewed / Open Access
• [Journal Article] Serotonin 5-HT7 receptor in the ventral hippocampus modulates the retrieval of fear memory and stress-induced defecation. (2016)
  • Author(s): Ohmura Y, Yoshida T, Konno K, Minami M, Watanabe M, Yoshioka M
  • Journal Title: Int J Neuropsychopharmacol. Volume: 19 Pages: 1-12
  • DOI: 10.1093/ijnp/pyv131
  • Peer Reviewed / Open Access
• [Journal Article] A combined electrophysiological and morphological study of neuropeptide Y-expressing inhibitory interneurons in the spinal dorsal horn of the mouse. (2016)
  • Author(s): Iwagaki, Noboru; Ganley, Robert P.; Dickie, Allen C.; Polgár, Erika; Hughes, David I.; Del Rio, Patricia; Revina, Yulia; Watanabe, Masahiko; Todd, Andrew J
  • Journal Title: PAIN Volume: 157 Pages: 598-612
  • DOI: 10.1097/j.pain.0000000000000407
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord. (2016)
  • Author(s): Ming-Dong Zhang,Swapnali Barde,Edit Szodorai,Anna Josephson,Nicholas Mitsios,Masahiko Watanabe,Johannes Attems,Gert Lubec,Gábor G. Kovács,Mathias Uhlén,Jan Mulder,Tibor Harkany, and Tomas Hökfelt.
  • Journal Title: Brain Structure and Function. Volume: 221 Pages: 3803-3823
  • DOI: 10.1007/s00429-016-1191-3.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards. (2016)
  • Author(s): Watanabe-Iida I, Konno K, Akashi K, Abe M, Natsume R, Watanabe M, Sakimura K.
  • Journal Title: J Neurochem. Volume: 136 Pages: 295-305
  • DOI: doi: 10.1111/jnc.13384
  • Peer Reviewed / Open Access
• [Journal Article] A quantitative study of neurochemically-defined excitatory interneuron populations in laminae I-III of the mouse spinal cord. (2016)
  • Author(s): Gutierrez-Mecinas M, Furuta T, Watanabe M, Todd A
  • Journal Title: Mol Pain Volume: 12 Pages: 1-18
  • DOI: 10.1177/1744806916629065
  • Peer Reviewed / Open Access
• [Journal Article] Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon, (2016)
  • Author(s): Kaji I, Akiba Y, Konno K, Watanabe M, Kimura S, Iwanaga T, Kuri A, Iwamoto K, Kuwahara A, Kaunitz JD
  • Journal Title: J Physiol, Volume: 594 Pages: 3339-3352
  • DOI: 10.1113/JP271441.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. (2016)
  • Author(s): Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y , Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M
  • Journal Title: Nat Commun, Volume: 7 Pages: 10594
  • DOI: 10.1038/ncomms10594.
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of hormones in olfactory imprinting and homing in chum salmon. (2016)
  • Author(s): Ueda H, Nakamura S, Nakamura T, Inada K, Ookubo T, Furukawa N, Murakami R, Tsuchida S, Zohar Y, Konno K, Watanabe M
  • Journal Title: Sci Rep. Volume: 6 Pages: 21102
  • DOI: 10.1038/srep21102.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination. (2016)
  • Author(s): Ichikawa R, Hashimoto K, Miyazaki T, Uchigashima M, Yamasaki M, Aiba A, Kano M, Watanabe M
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 113 Pages: 2282-2287
  • DOI: 10.1073/pnas.1511513113.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function. (2016)
  • Author(s): Kim G, Lujan R, Schwenk J, Kelley M, Aguado C, Watanabe M, Fakler B, Maylie J, Adelman JP
  • Journal Title: eLife Volume: - Pages: Epub
  • DOI: 10.7554/eLife.12637.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures. (2016)
  • Author(s): Uchigashima M, Ohtsuka T, Kobayashi K, Watanabe M
  • Journal Title: Proc Natl Acad Sci USA Volume: 113 Pages: 4206-4211
  • DOI: 10.1073/pnas.1514074113.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TARP gamma-2 and gamma-8 differentially control biased AMPAR density across Schaffer collateral/commissural synapses in the hippocampal CA1. (2016)
  • Author(s): Yamasaki M, Fukaya M, Yamazaki M, Azechi H, Natsume R, Abe M, Sakimura K, Watanabe M
  • Journal Title: J Neurosci, Volume: 36 Pages: 4296-4312
  • DOI: 10.1523/JNEUROSCI.4178-15.2016.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synaptic and cellular changes induced by the schizophrenia susceptibility gene G72 are rescued by N-acetylcysteine treatment. (2016)
  • Author(s): Posfai B, Cserep C, Hegedus P, Szabadits E, Otte D, Zimmer A, Watanabe M, Freund TF, Nyiri G
  • Journal Title: Transl Psychiat, Volume: 6 Pages: e807
  • DOI: 10.1038/tp.2016.74.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GluD2 endows parallel fiber-Purkinje cell synapses with a high regenerative capacity. (2016)
  • Author(s): Ichikawa R, Sakimura K, Watanabe M
  • Journal Title: J Neurosci, Volume: 36 Pages: 4846-4858
  • DOI: 10.1523/JNEUROSCI.0161-16.2016.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trans-synaptic modulation of kainate receptor functions by C1q-like proteins. (2016)
  • Author(s): Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa K, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K,
  • Journal Title: Neuron Volume: 90 Pages: 752-767
  • DOI: 10.1016/j.neuron.2016.04.001. Epub 2016 Apr 28.
  • Peer Reviewed / Open Access
• [Journal Article] Medial septal GABAergic projection neurons promote object exploration behavior and Type 2 theta rhythm. (2016)
  • Author(s): Gangadharan G, Shin J, Kim S-W, Kim A, Paydar A, Kim D-S, Miyazaki T, Watanabe M, Yanagawa Y, Kim J, Kim Y-S, Kim D, Shin H-S.
  • Journal Title: Proc. Natl. Acad. Sci. USA, Volume: 113 Pages: 6550-6555
  • DOI: 10.1073/pnas.1605019113.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immunostaining for Homer reveals the majority of excitatory synapses in laminae I-III of the mouse spinal dorsal horn. (2016)
  • Author(s): Gutierrez-Mecinas M, Polgar E, Watanabe M, Abraira VE, Todd AJ
  • Journal Title: Neuroscience Volume: 329 Pages: 171-181
  • DOI: 10.1016/j.neuroscience.2016.05.009.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Developmental switch in spike timing-dependent plasticity and cannabinoid-dependent reorganization of the thalamocortical projection in the barrel cortex. (2016)
  • Author(s): Itami C, Huang JY, Yamasaki M, Watanabe M, Lu H, Kimura F
  • Journal Title: J Neurosci, Volume: 36 Pages: 7039-7054
  • DOI: 10.1523/JNEUROSCI.4280-15.2016.
  • Peer Reviewed / Open Access
• [Journal Article] Distinct subunit domains govern synaptic stability and specificity of the kainate receptor. (2016)
  • Author(s): Straub C, Noam Y, Nomura T, Yamasaki M, Yan D, Fernandes H, Watanabe M, Contractor A, Tomita S
  • Journal Title: Cell Rep. Volume: 16 Pages: 531-534
  • DOI: 10.1016/j.celrep.2016.05.093.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus. (2016)
  • Author(s): Kobayashi S, Hida Y, Ishizaki H, Inoue E, Tanaka-Okamoto M, Yamasaki M, Miyazaki T, Masahiro F, Kitajima I, Takai Y, Watanabe M, Ohtsuka T, Manabe T
  • Journal Title: Eur J Neurosci. Volume: 44 Pages: 2272-2284
  • DOI: 10.1111/ejn.13331.
  • Open Access
• [Journal Article] Ionic basis for membrane potential resonance in neurons of the inferior olive. (2016)
  • Author(s): Matsumoto-Makidono Y, Nakayama H, Watanabe M, Kano M, Sakimura K, Hashimoto K
  • Journal Title: Cell Rep Volume: 16 Pages: 994-1004
  • DOI: 10.1016/j.celrep.2016.06.053.
  • Peer Reviewed / Open Access
• [Journal Article] Crucial roles of the endocannabinoid 2-arachidonoylglycerol in the suppression of epileptic seizures. (2016)
  • Author(s): Sugaya Y, Yamazaki M, Uchigashima M, Kobayashi K, Watanabe M, Sakimura K, Kano M
  • Journal Title: Cell Rep Volume: 16 Pages: 1405-1415,
  • DOI: 10.1016/j.celrep.2016.06.083.
  • Peer Reviewed / Open Access
• [Journal Article] KCTD12 auxiliary proteins modulate kinetics of GABAB receptor-mediated inhibition in cholecystokinin-containing interneurons. (2016)
  • Author(s): Booker SA, Althof D, Gross A, Loreth D, Müller J, Unger A, Fakler B, AVarro A, Watanabe M, Gassmann M, Bettler B, Shigemoto R, Vida I, Kulik A
  • Journal Title: Cereb Cortex Volume: 27 Pages: 2318-2334
  • DOI: 10.1093/cercor/bhw090
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Locus coeruleus and dopaminergic consolidation of everyday memory. (2016)
  • Author(s): Takeuchi T, Duszkiewicz AJ, Sonneborn A, Spooner PA, Yamasaki M, Watanabe M, Smith GC, Fernández G, Deisseroth K, Greene RW, Morris RGM
  • Journal Title: Nature, Volume: 537 Pages: 357-362
  • DOI: 10.1038/nature19325.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distribution of corticotropin-releasing factor neurons in the mouse brain: a study using corticotropin-releasing factor-modified yellow fluorescent protein knock-in mouse (2016)
  • Author(s): Kono J,:Konno K, Talukder AH, Fuse T, Abe M, Uchida K, Horio S, Sakimura K, Watanabe M, Itoi K
  • Journal Title: Brain Struc Funct Volume: Epub ahead of print Pages: Epub
  • DOI: 10.1007/s00429-016-1303-0
  • Peer Reviewed / Open Access
• [Journal Article] Differential expression of endothelial nutrient transporters (MCT1 and GLUT1) in the developing eyes of mice (2016)
  • Author(s): Kishimoto A, Iwanaga T, Takahashi-Iwanaga T, Watanabe M
  • Journal Title: Exp Eye Res Volume: 153 Pages: 170-177
  • DOI: 10.1016/j.exer.2016.10.019.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling. (2016)
  • Author(s): Kitajima N, Numaga-Tomita T, Watanabe M, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M
  • Journal Title: Sci Rep Volume: 6 Pages: 37001
  • DOI: 10.1038/srep37001.
  • Peer Reviewed / Open Access
• [Journal Article] The metabotropic glutamate receptor subtype 1 mediates experience-dependent maintenance of mature synaptic connectivity in the visual thalamus. (2016)
  • Author(s): Narushima M, Uchigashima M, Yagasaki Y, Harada T, Nagumo Y, Uesaka N, Hashimoto K, Aiba A, Watanabe M, Miyata M, Kano M
  • Journal Title: Neuron Volume: 91 Pages: 1097-1109
  • DOI: 10.1016/j.neuron.2016.07.035.
  • Peer Reviewed / Open Access
• [Journal Article] Astrocyte-mediated infantile-onset leukoencephalopathy mouse model. (2016)
  • Author(s): Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M, Fukata M, Ikenaka K, Tanaka KF
  • Journal Title: Glia Volume: 65 Pages: 150-156
  • DOI: 10.1002/glia.23084.
  • Peer Reviewed / Open Access
• [Journal Article] Roles of Cbln1 in non-motor functions of mice. (2016)
  • Author(s): Otsuka S, Konno K, Abe M, Motohashi J, Kohda K, Sakimura K, Watanabe M, Yuzaki M
  • Journal Title: J. Neurosci. Volume: 36 Pages: 11801-11816
  • DOI: 10.1523/JNEUROSCI.0322-16.2016
  • Peer Reviewed / Open Access
• [Journal Article] Distinct and Cooperative Functions for the Protocadherin-alfa, -beta and -ganma Clusters in Neuronal Survival and Axon Targeting. (2016)
  • Author(s): Hasegawa S, Kumagai M, Hagiwara M, Nishimaru H, Hirano K, Kaneko R, Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M, Hirabayashi T, Yagi T
  • Journal Title: Front Mol Neurosci, Volume: 9 Pages: 155
  • DOI: 10.3389/fnmol.2016.00155.
  • Peer Reviewed / Open Access
• [Journal Article] Late developmental alterations in GABAergic and glutamatergic neural networks containing parvalbumin and/or nitric oxide synthase in the mouse inferior colliculus. (2016)
  • Author(s): Fujimoto H, Konno K, Watanabe M, Jinno S
  • Journal Title: J Comp Neurol Volume: 525 Pages: 868-884
  • DOI: 10.1002/cne.24104.
  • Peer Reviewed / Open Access
• [Presentation] マウス線条体シナプスのAMPA受容体密度は細胞種や出入力経路によらず一様である (2017)
  • Author(s): 山崎美和子、宋暁紅、渡辺雅彦
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学（長崎県）
  • Year and Date: 2017-03-28 – 2017-03-30
• [Presentation] 分界条床核におけるGluD1/Cbln1複合体は結合腕傍核との非シナプス性接着構造の形成と維持に必須である (2017)
  • Author(s): 今野幸太郎、森さくら、崎村建司、柚崎通介、渡辺雅彦
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学（長崎県）
  • Year and Date: 2017-03-28 – 2017-03-30
• [Presentation] カルシニューリンB1サブユニットCNB1は登上線維－プルキンエ細胞単一支配化および抑制性シナプス回路形成に重要であるCalcineurin B1 subunit is essential for climbing fiber mono-innervation and inhibitory synapse formation in cerebellar Purkinje cells (2017)
  • Author(s): Taisuke Miyazaki, Kenji Sakimura , Masahiko Watanabe
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学（長崎県）
  • Year and Date: 2017-03-28 – 2017-03-30
• [Presentation] 分界条床核におけるGluD1/Cbln1複合体は、結合腕傍核由来神経終末とのシナプスの形成と維持に必須である (2016)
  • Author(s): 今野幸太郎、森さくら、崎村建司、柚崎通介、渡辺雅彦
  • Organizer: 第62回東北・北海道連合支部学術集会
  • Place of Presentation: 帯広畜産大学（北海道）
  • Year and Date: 2016-09-03 – 2016-09-04
• [Presentation] Cav2.1 is indispensable to maintain wiring, survival, and compartmentalized expression in adult cerebellar Purkinje cells.カルシウムチャネルCav2.1は成体期プルキンエ細胞のシナプス回路、生存、バンド状発現の維持に不可欠である (2016)
  • Author(s): Taisuke Miyazaki, Miwako Yamasaki, Kenji Sakimura, Masahiko Watanabe
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2016-07-20 – 2016-07-22
• [Presentation] GluD1 and Cbln1 interaction plays an important role in synapse formation between particular neurochemical neurons in the parabigeminal nucleus and dorsolateral geniculate nucleus. (2016)
  • Author(s): Kohtarou Konno, Koji Nishikawa, Shinji Yamada, Kenji Sakimura, Michisuke Yuzaki, Masahiko Watanabe.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2016-07-20 – 2016-07-22
• [Book] Receptor and Ion Channel Detection in the Brain, Neuromethods (2016)
  • Author(s): Watanabe M
  • Total Pages: 3-18
  • Publisher: Humana Press, New York
• [Book] Receptor and Ion Channel Detection in the Brain, Neuromethods (2016)
  • Author(s): Yamasaki M, Watanabe M
  • Total Pages: 127-142
  • Publisher: Humana Press, New York
• [Book] Receptor and Ion Channel Detection in the Brain, Neuromethods (2016)
  • Author(s): Konno K, Watanabe M
  • Total Pages: 171-178
  • Publisher: Humana Press, New York
• [Book] Receptor and Ion Channel Detection in the Brain, Neuromethods (2016)
  • Author(s): Lujan R, Watanabe M
  • Total Pages: 211-232
  • Publisher: Humana Press, New York
• [Book] Essentials of Cerebellum and Cerebellar Disorders (2016)
  • Author(s): Hashimoto K, Watanabe M, Kano M
  • Total Pages: 161-165
  • Publisher: Springer
• [Book] Essentials of Cerebellum and Cerebellar Disorders (2016)
  • Author(s): Watanabe M
  • Total Pages: 195-199
  • Publisher: Springer