Establishment of an IL-1-related gene-manipulated mouse library and dissection of the gene-targeted mice, aiming at identifying new therapeutic targets for diseases

2016 Fiscal Year Annual Research Report

• Project/Area Number: 24220011
• Research Institution: Tokyo University of Science
• Principal Investigator: 岩倉 洋一郎 東京理科大学, 研究推進機構生命医科学研究所, 教授 (10089120)
• Co-Investigator(Kenkyū-buntansha): 西城 忍 千葉大学, 真菌医学研究センター, 准教授 (60396877) ; 島津 朋之 東京理科大学, 研究推進機構生命医科学研究所, 助教 (20616437)
• Project Period (FY): 2012-05-31 – 2017-03-31
• Keywords: 遺伝子改変マウス / C型レクチン / C1qTNF

Outline of Annual Research Achievements

本研究ではIL-1およびその下流で活性化されるC型レクチン受容体ファミリーおよびC1qTNFファミリーの自己免疫やアレルギー、骨代謝などに於ける機能解析に基づき、これらの分子の生体の恒常性維持や疾病に於ける役割を解明すると共に、治療への糸口を見いだすことを目的として研究を行った。その結果、本年度は以下の成果を得た。１）IL-1関連遺伝子の機能解析として、IL-1が胸腺T細胞の分化に影響を与え、自己免疫疾患発症に関与していることを見出し、現在投稿準備中である。またIL-1F6欠損マウスでは乾癬の症状が緩和することを見出し、論文をリバイス中である。２）C型レクチンファミリー分子の解析では、Dectom-1, 2以外にも複数の分子が真菌感染防御に関与することを見出すと共に、一部は結核菌に対する感染防御に関与することを見出した。また、これらのファミリー分子の一部は大腸がんの発症に関与していることを明らかにした。現在そのメカニズムを解析している。３）C1qTNFファミリー分子の解析では、CTRP6が腎炎の発症に関与すること、CTRP3が免疫細胞の活性化を制御して自己免疫疾患の発症を抑制することを明らかにした。また、当初作製を予定していた8系統の遺伝子改変マウスのうち、7系統の遺伝子欠損マウスの作製に成功すると共に、当初の予定になかった3系統の遺伝子欠損マウスの作製に成功した。これらのうち、3系統の遺伝子欠損マウスはゲノム編集技術CRISPR/Cas9システムを用いて作製したものである。これまでに作製した遺伝子改変マウスはバイオリソースとしてHP上に公開し供給を行っている。平成24年度から現在までに国内外の研究施設に200件以上の供給を行った。この結果、サイトカインやC型レクチン受容体の疾病や生体の恒常性維持に於ける役割の理解が格段に深まった。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. (2017)
  • Author(s): Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, Inaba K, Takahara K.
  • Journal Title: Eur J Immunol. Volume: 47 Pages: 704-712
  • DOI: 10.1002/eji.201646814
  • Peer Reviewed
• [Journal Article] IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin. (2017)
  • Author(s): Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M.
  • Journal Title: Dermatol. Volume: 26 Pages: 137-144
  • DOI: 10.1111/exd.13115
  • Peer Reviewed / Open Access
• [Journal Article] Preferentially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice. (2017)
  • Author(s): Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F.
  • Journal Title: Eur J Immunol. Volume: 47 Pages: 685-691
  • DOI: 10.1002/eji.201646699
  • Peer Reviewed / Open Access
• [Journal Article] Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells. (2017)
  • Author(s): Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H.
  • Journal Title: J Immunol. Volume: 198 Pages: 61-70
  • DOI: 10.4049/jimmunol.1502393
  • Peer Reviewed
• [Journal Article] Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells. (2017)
  • Author(s): Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M
  • Journal Title: Stem Cells. Volume: 35 Pages: 989-1002
  • DOI: 10.1002/stem.2524.
  • Peer Reviewed / Open Access
• [Journal Article] Isolation of joint-infiltrating cells. (2016)
  • Author(s): Akitsu A, Iwakura Y.
  • Journal Title: Bio-Protocol. Volume: 6 Pages: -
  • DOI: 10.21769/BioProtoc.1911
  • Open Access
• [Journal Article] Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. (2016)
  • Author(s): Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
  • Journal Title: Immunity. Volume: 45 Pages: 1299-1310
  • DOI: 10.1016/j.immuni.2016.11.010.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection. Immun (2016)
  • Author(s): Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G. Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection.
  • Journal Title: Immun Inflamm Dis. Volume: 4 Pages: 401-412
  • DOI: 10.1002/iid3.121
  • Peer Reviewed / Open Access
• [Journal Article] The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis. (2016)
  • Author(s): Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 113 Pages: 14097-14102
  • DOI: 10.1073/pnas.1617903113
  • Peer Reviewed / Open Access
• [Journal Article] Two Types of Interleukin 17A-Producing γδ T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae. (2016)
  • Author(s): Murakami T, Hatano S, Yamada H, Iwakura Y, Yoshikai Y.
  • Journal Title: J Infect Dis. Volume: 214 Pages: 1752-1761
  • DOI: 10.1093/infdis/jiw443
  • Peer Reviewed / Open Access
• [Journal Article] IL-21 inhibits IL-17A-producing γδ T-cell response after infection with Bacillus Calmette-Guerin via induction of apoptosis. (2016)
  • Author(s): Huang Y, Matsumura Y, Hatano S, Noguchi N, Murakami T, Iwakura Y, Sun X, Ohara N, Yoshikai Y.
  • Journal Title: Innate Immun. Volume: 22 Pages: 588-597
  • DOI: 10.1177/1753425916664125
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. (2016)
  • Author(s): Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.
  • Journal Title: Diabetes. Volume: 65 Pages: -
  • DOI: 10.2337/db16-ec08a
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] IL-17A exacerbates cisplatin-based resistance of OVCA via upregulating the expression of ABCG2 and MDR1 through Gli1-mediated Hh signaling. (2016)
  • Author(s): Niu X, Liu W, Wang Y, Liu X, Zhang H, Li Z, Li H, Iwakura Y, Deng W.
  • Journal Title: Oncotarget Volume: 印刷中 Pages: 印刷中
  • DOI: 10.18632/oncotarget.10655
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The potential for repositioning antithyroid agents as antiasthma drugs. (2016)
  • Author(s): Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
  • Journal Title: J Allergy Clin Immunol. Volume: 138 Pages: 1458-1461
  • DOI: 10.1016/j.jaci.2016.04.047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression. (2016)
  • Author(s): Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
  • Journal Title: Cancer Sci. Volume: 107 Pages: 1206-1214
  • DOI: 10.1111/cas.13005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells. (2016)
  • Author(s): Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
  • Journal Title: J Biol Chem. Volume: 291 Pages: 17629-38
  • DOI: 10.1074/jbc.M116.741256
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation. (2016)
  • Author(s): Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M.
  • Journal Title: Immunity Volume: 44 Pages: 1422-33
  • DOI: 10.1016/j.immuni.2016.05.010
  • Peer Reviewed
• [Journal Article] Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. (2016)
  • Author(s): Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA.
  • Journal Title: J Immunol. Volume: 197 Pages: 278-87
  • DOI: 10.4049/jimmunol.1502485
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis. (2016)
  • Author(s): Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S.
  • Journal Title: Innate Immun. Volume: 22 Pages: 316-24
  • DOI: 10.1177/1753425916645392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. (2016)
  • Author(s): Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS.
  • Journal Title: Hypertension Volume: 68 Pages: 167-74
  • DOI: 10.1161/HYPERTENSIONAHA.116.07493
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system. (2016)
  • Author(s): Shishikura M, Nakamura F, Yamashita N, Uetani N, Iwakura Y, Goshima Y.
  • Journal Title: Brain Res. Volume: 1642 Pages: 244-54
  • DOI: 10.1016/j.brainres.2016.03.030
  • Peer Reviewed / Open Access
• [Journal Article] T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. (2016)
  • Author(s): Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.
  • Journal Title: Nat Immunol. Volume: 17 Pages: 583-92
  • DOI: 10.1038/ni.3389
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy. (2016)
  • Author(s): Javed N, Xue G, Lu A, Xing Y, Iwakura Y, Xiao H, Lecoeur H, Spath GF, Meng G.
  • Journal Title: Cytokine Volume: 81 Pages: 101-8
  • DOI: 10.1016/j.cyto.2016.03.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo. (2016)
  • Author(s): Ciraci C, Janczy JR, Jain N, Haasken S, Pecli E Silva C, Benjamim CF, Sadler JJ, Olivier AK, Iwakura Y, Shayakhmetov DM, Sutterwala FS, Cassel SL.
  • Journal Title: PLoS One Volume: 11 Pages: -
  • DOI: 10.1371/journal.pone.0151252
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-17-producing γδ T cells enhance bone regeneration. (2016)
  • Author(s): Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H.
  • Journal Title: Nat Commun. Volume: 7 Pages: -
  • DOI: 10.1038/ncomms10928
  • Peer Reviewed / Open Access
• [Journal Article] Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye. (2016)
  • Author(s): Lee EJ, Brown BR, Vance EE, Snow PE, Silver PB, Heinrichs D, Lin X, Iwakura Y, Wells CA, Caspi RR, Rosenzweig HL.
  • Journal Title: J. Immunol. Volume: 196 Pages: 3148-58
  • DOI: 10.4049/jimmunol.1502355
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. (2016)
  • Author(s): Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Cappelletti M, Huppert SS, Iwakura Y, Dong C, Shanmukhappa SK, Divanovic S.
  • Journal Title: PLoS One Volume: 11 Pages: -
  • DOI: 10.1371/journal.pone.0149783
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice. (2016)
  • Author(s): Kawabe T, Suzuki N, Yamaki S, Sun SL, Asao A, Okuyama Y, So T, Iwakura Y, Ishii N.
  • Journal Title: Eur J Immunol. Volume: 46 Pages: 1119-31
  • DOI: 10.1002/eji.201545907
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway. (2016)
  • Author(s): Mai J, Nanayakkara G, Lopez-Pastrana J, Li X, Li YF, Wang X, Song A, Virtue A, Shao Y, Shan H, Liu F, Autieri MV, Kunapuli SP, Iwakura Y, Jiang X, Wang H, Yang XF.
  • Journal Title: J Biol Chem. Volume: 291 Pages: 4939-54
  • DOI: 10.1074/jbc.M115.690081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Roles of C-type lectins in host defense against pathogens and homeostasis of the immune system. (2017)
  • Author(s): Yoichiro Iwakura
  • Organizer: Genomics Research Center Seminar Series
  • Place of Presentation: Taipei, ROC
  • Year and Date: 2017-03-02
  • Int'l Joint Research / Invited
• [Presentation] 低分子βグルカンによる腸管免疫の制御 (2017)
  • Author(s): 岩倉洋一郎
  • Organizer: 第１回プロバイオティクス学術セミナー
  • Place of Presentation: アパホテル＆リゾート東京ベイ幕張
  • Year and Date: 2017-02-24
  • Invited
• [Presentation] 炎症性腸疾患と食物アレルギーの病態制御におけるDectin-1と短鎖βグルカンの役割の解析 (2017)
  • Author(s): 唐策、岩倉洋一郎
  • Organizer: Glyco-Immunology 2017糖鎖免疫研究会
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2017-01-25
  • Invited
• [Presentation] 炎症性疾患及び免疫系の恒常性維持におけるIL－17の役割 (2017)
  • Author(s): 岩倉洋一郎
  • Organizer: 第40回皮膚脈管・膠原病研究会
  • Place of Presentation: コラッセ福島
  • Year and Date: 2017-01-21
  • Invited
• [Presentation] Pathogenic Mechanisms of Psoriasis: Lessons from Mouse Models (2016)
  • Author(s): Yoicihiro Iwakura
  • Organizer: 日本研究皮膚科学会第41回年次学術大会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-12-10
  • Int'l Joint Research / Invited
• [Presentation] A novel role of Dectin-1 signaling in controlling food antigen-induced mouse intestinal allergy (2016)
  • Author(s): 唐策、濱田有史、岩倉洋一郎
  • Organizer: 第45回日本免疫学会学術集会.
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2016-12-05 – 2016-12-07
• [Presentation] Identification of novel IL-17-producing T cell populations, γδ TCR-CD4-CD8- cells, in TCRδ -deficient mice. (2016)
  • Author(s): Aoi Akitsu, Yoichiro Iwakura.
  • Organizer: 4th Annual Meeting of the International Cytokine & Interferon Society (ICIS).
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2016-10-16 – 2016-10-19
  • Int'l Joint Research
• [Presentation] 補体制御因子CTRP6と炎症性疾患 (2016)
  • Author(s): 村山正承、岩倉洋一郎
  • Organizer: 第3回日本リウマチ学会ベーシックリサーチカンファレンス
  • Place of Presentation: 富士ソフト アキバプラザ 5階アキバホール
  • Year and Date: 2016-10-14 – 2016-10-15
• [Presentation] 低分子βグルカンによる腸管炎症抑制 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: バイオジャパン
  • Place of Presentation: 東京理科大学
  • Year and Date: 2016-10-12
  • Invited
• [Presentation] 疾患モデルを用いた自己免疫および感染防御機構の解析と創薬への展開 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 自治医科大学大学院特別講義（医学研究科教育委員会主催）
  • Place of Presentation: 自治医科大学
  • Year and Date: 2016-10-04
  • Invited
• [Presentation] The role of C-type lectin receptors in the homeostasis of the intestinal immune system. (2016)
  • Author(s): Yoichiro Iwakura
  • Organizer: National Defense Medical Center (Sponsored by Prof. Ann Chen)
  • Place of Presentation: Taipei, ROC
  • Year and Date: 2016-09-16
  • Int'l Joint Research / Invited
• [Presentation] 短鎖βグルカンによる腸管免疫恒常性の維持 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 日本臨床免疫学会シンポジウム
  • Place of Presentation: 京王プラザ、東京
  • Year and Date: 2016-09-08
  • Int'l Joint Research / Invited
• [Presentation] 自然免疫受容体を介した真菌の認識と免疫系の修飾 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 日本医真菌学会教育講演
  • Place of Presentation: 都立産業貿易センター
  • Year and Date: 2016-09-08
  • Int'l Joint Research / Invited
• [Presentation] 短鎖βグルカンによる腸内細菌を介した免疫制御 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 東海大学医学部講演会
  • Place of Presentation: 東海大学医学部
  • Year and Date: 2016-09-06
  • Invited
• [Presentation] DCIR－糖鎖間相互作用による骨代謝制御機構 (2016)
  • Author(s): 矢部力朗、海部知則、丸橋拓海、西城忍、舘野浩章、平林淳、岩倉洋一郎
  • Organizer: 第35回日本糖質年会
  • Place of Presentation: 高知市文化プラザかる ぽーと
  • Year and Date: 2016-09-01 – 2016-09-03
• [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine. (2016)
  • Author(s): Ce Tang, Tomonori Kamina, Yoichiro Iwakura.
  • Organizer: International Congress of Immunology (ICI) 2016
  • Place of Presentation: Melbourne, Australia.
  • Year and Date: 2016-08-21 – 2016-08-26
• [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells. (2016)
  • Author(s): Aoi Akitsu, Yoichiro Iwakura.
  • Organizer: International Congress of Immunology (ICI) 2016
  • Place of Presentation: Melbourne, Australia.
  • Year and Date: 2016-08-21 – 2016-08-26
  • Int'l Joint Research
• [Presentation] 自己免疫疾患と感染防御におけるIL－17ファミリーの役割 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: Psoriasis and IL-17A Forum 2016 in Kyushu
  • Place of Presentation: 博多エクセルホテル東急
  • Year and Date: 2016-07-30
  • Invited
• [Presentation] 自己免疫疾患と感染防御におけるIL－17ファミリーの役割 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 四国４大学皮膚科研究会
  • Place of Presentation: 松山全日空ホテル
  • Year and Date: 2016-07-23
  • Invited
• [Presentation] Complement regulator CTRP6 and inflammatory diseases. (2016)
  • Author(s): Masanori A. Murayama, Kenzo Matsuo, Kaori Yoshida, Nanako Katagiri, Yoichiro Iwakura.
  • Organizer: 9th International Conference on Complement Therapeutics.
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 2016-06-28 – 2016-07-03
  • Int'l Joint Research
• [Presentation] 真菌によるIL-17産生機構 (2016)
  • Author(s): 西城忍
  • Organizer: AMED-CREST若手研究会
  • Place of Presentation: 大阪アカデミア
  • Year and Date: 2016-06-15 – 2016-06-16
  • Invited
• [Presentation] 炎症および感染防御におけるIL－17AとIL－17Fの役割 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 皮膚科学会モーニングセミナー
  • Place of Presentation: 京都国際会館
  • Year and Date: 2016-06-04
  • Invited
• [Presentation] 自己免疫疾患と感染防御におけるIL－17ファミリーの役割 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 御茶ノ水乾癬勉強会
  • Place of Presentation: TKRガーデンシティー御茶ノ水
  • Year and Date: 2016-05-21
  • Invited
• [Presentation] The role of C-type lectin receptors in the homeostasis of the intestinal immune system. (2016)
  • Author(s): Yoichiro Iwakura
  • Organizer: Korean Society for Biochemistry and Molecular Biology (KSBMB) International Conference 2016
  • Place of Presentation: Korea, Coex, Seoul
  • Year and Date: 2016-05-18
  • Int'l Joint Research / Invited
• [Presentation] IL-1Ra KOマウスにおける胸腺T細胞分化の解析. (2016)
  • Author(s): 秋津葵、岩倉洋一郎
  • Organizer: 第26回Kyoto T cells conference.
  • Place of Presentation: 比叡山延暦寺内比叡山会館
  • Year and Date: 2016-05-13 – 2016-05-17
• [Presentation] 補体制御因子CTRP6と炎症性疾患 (2016)
  • Author(s): 村山正承、松尾謙蔵、吉田佳織、片桐菜々子、岩倉洋一郎
  • Organizer: 第81回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 長崎大学坂本キャンパス良順会館
  • Year and Date: 2016-05-13 – 2016-05-14
• [Presentation] 自然免疫による病原体防御の新展開 (2016)
  • Author(s): 西城忍
  • Organizer: 第8回に本インターフェロン・サイトカイン学術集会
  • Place of Presentation: 長崎大学良順会館
  • Year and Date: 2016-05-13 – 2016-05-14
  • Invited
• [Presentation] シンポジウム17「リウマチ性疾患における自己免疫と自然免疫」 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 第６０回日本リウマチ学会総会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-04-23
  • Invited
• [Book] トピックス 「自己免疫疾患に対する新たな治療標的の発見」 (2017)
  • Author(s): 村山正承、岩倉洋一郎
  • Total Pages: 4
  • Publisher: 理大科学フォーラム
• [Book] セミナー室「低分子βグルカン摂取により炎症性腸疾患を予防，改善する」 (2016)
  • Author(s): 唐策、角田茂、岩倉洋一郎
  • Total Pages: 6
  • Publisher: 日本農芸化学会
• [Book] Dendritic Cell Immunoreceptor (DCIR): An ITIM-Harboring C-Type Lectin Receptor. (2016)
  • Author(s): Tomonori Kaifu and Yoichiro Iwakura.
  • Total Pages: 12
  • Publisher: Springer Japan
• [Book] IL－1ファミリー分子による免疫制御 (2016)
  • Author(s): 秋津葵、岩倉洋一郎
  • Total Pages: 7
  • Publisher: 科学評論社
• [Book] 医歯薬出版株式会社 (2016)
  • Author(s): 秋津葵、岩倉洋一郎
  • Total Pages: 5
  • Publisher: 自己免疫性関節炎と病原性T細胞
• [Book] Chronic inflammation (2016)
  • Author(s): Saijo S
  • Total Pages: 12
  • Publisher: Springer Japan
• [Book] C-type lectin receptors in immunity (2016)
  • Author(s): Yabe R. and Saijo S.
  • Total Pages: 12
  • Publisher: Springer Japan
• [Remarks] 東京理科大学生命医科学研究所実験動物学研究部門
  • URL: http://www.rs.tus.ac.jp/iwakuralab/
• [Remarks] 東京理科大学生命医科学研究所ヒト疾患モデル研究センター
  • URL: http://www.ribs.tus.ac.jp/index.php/cadm/
• [Remarks] 千葉大学真菌医学研究センター感染免疫分野
  • URL: http://cytokine.pf.chiba-u.jp/