Mechanism regulating germline sex determination in Drosophila

2015 Fiscal Year Final Research Report

• Project/Area Number: 24247011
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: University of Tsukuba (2015); Okazaki Research Facilities, National Institutes of Natural Sciences
• Principal Investigator: KOBAYASHI Satoru 筑波大学, 生命領域学際研究センター, 教授 (90225508)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 生殖細胞 / 性決定 / ショウジョウバエ / ヒドラ / 始原生殖細胞

Outline of Final Research Achievements

In this study, we have been trying to clarify the mechanism regulating sex determination of the germline. Here, we report the identification of the candidate genes downstream of Sxl, which can autonomously initiate female development in primordial germ cells. Furthermore, we have performed a genomewide identification of the genes differentially expressed between male and female germline in Drosophila and Hydra. These results provide the basis for clarifying the conserved mechanism of germline sex determination in animals.

Free Research Field

基礎生物学・発生生物学