Defence mechanism against environmental chemicals in livestock animals

2015 Fiscal Year Final Research Report

• Project/Area Number: 24248056
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Boundary agriculture
• Research Institution: Hokkaido University
• Principal Investigator: ISHIZUKA MAYUMI 北海道大学, (連合)獣医学研究科, 教授 (50332474)
• Co-Investigator(Kenkyū-buntansha): IKENAKA Yoshinori 北海道大学, 大学院獣医学研究科, 准教授 (40543509)
• Co-Investigator(Renkei-kenkyūsha): TSUBOTA Toshio 北海道大学, 大学院獣医学研究科, 教授 (10207441) ; KONNAI Satoru 北海道大学, 大学院獣医学研究科, 准教授 (40396304)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: シトクロムP450 / グルクロン酸抱合 / 環境汚染 / 産業動物

Outline of Final Research Achievements

In livestock animals, we identified the enzymatic characters of cytochrome P450 as typical phase I enzyme for xenobiotics. We also analyzed glucronyltrasnferase and sulfotransferase dependent metabolites in urine samples from mammalians including livestock animals, to elucidate the ability of xenobiotic conjugating detoxification.　In field surveillance at Asia and African countries, heavy metals are major accumulated environmental pollutants in cattle, and the accumulating pattern is unique in ruminants. In case of poultry species, we clarify the expressed cytochrome P450 and phase II enzymes in liver using transcriptome analyses method and in silico analyses, and we compared the structure of xenobiotic metabolizing enzymes in poultry species to those of mammals.

Free Research Field

境界農学