Elucidation of cellular and molecular machinery to elaborate the barrel area specific cytoarchitecture in the mouse cerebral cortex

2016 Fiscal Year Final Research Report

• Project/Area Number: 24300130
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Inoue Takayoshi 国立研究開発法人国立精神・神経医療研究センター, 疾病研究第六部, 室長 (20370984)
• Research Collaborator: INOUE YUKIKO 国研)国立精神・神経医療研究センター, 神経研究所, 科研費研究員 ; ASAMI JUNKO 国研)国立精神・神経医療研究センター, 神経研究所, センター研究補助員 ; TERAKAWA YOUHEI 国研)国立精神・神経医療研究センター, 神経研究所, 研究生 ; EGUSA SAKI 国研)国立精神・神経医療研究センター, 神経研究所, 研究生 ; HIRAGA KOU 国研)国立精神・神経医療研究センター, 神経研究所, 流動研究員
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: 脳・神経 / 発現制御 / ゲノム / 細胞・組織 / 発生・分化 / 大脳皮質 / 機能領野 / カドヘリン

Outline of Final Research Achievements

This research project mostly aims to reveal cellular and molecular machinery for cortical arealization by systematically analyzing gene regulatory mechanism and function of each subclass of cell-cell and synapse adhesion molecules, cadherins, whose expression distinctively demarcates tangential units in the postnatal mouse cerebral cortex. As the results, it has been clarified that neuronal activity dependent expression profiles of cadherin subclasses with differential selective adhesiveness cooperatively balance postnatal neuronal positioning and dendrite dynamics to elaborate the specific cytoarchitecture of a mouse cortical area, somatosensory barrels, within the period of the first postnatal week.

Free Research Field

分子神経発生生物学