X-ray movie system for analysis of Parkinson disease and rehabilitation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24300190
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KUMEI Yasuhiro 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (30161714)
• Co-Investigator(Kenkyū-buntansha): 長谷川 克也 宇宙航空研究開発機構 (30425780) ; 粟生 修司 九州工業大学 (40150908) ; KA井上 東京医科歯科大学 (90302877)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: X線 / パーキンソン病 / リハビリテーション / 運動障害 / 呼吸機能 / 横隔膜

Outline of Final Research Achievements

Parkinson’s disease is a progressive degenerative CNS disorder to cause a typical motor symptoms. Respiratory alterations have been supposed to follow postural changes and osteoarticular degeneration, leading to an alteration in the spinal axis that in turn could affect breathing mechanics. We examined respiratory movements by using cineradiography on a model of mild hemi-Parkinson disease by an injection of 6-OHDA solution to the right striatum of mice (C57BL/6J), and were compared to control mice that were injected with saline solution. Two weeks after surgery, respiratory movements were recorded by video X-ray without restraint. Behavioral tests confirmed mild motor impairments in Parkinson mice. Parameters of respiratory function showed mild alterations in the Parkinson mice, suggestive of a restrictive-type respiratory disorder. Data suggest that respiratory alterations in Parkinson disease may emerge simultaneously to motor symptoms, and not as a consequence of the latter.

Free Research Field

硬組織病態生化学