2012 Fiscal Year Annual Research Report
健康科学と臨床医学を統合した日本人における生活習慣病の予防・治療のエビデンス確立
| Project/Area Number |
24300233
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Research Institution | Niigata University |
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Principal Investigator |
曽根 博仁 新潟大学, 医歯学系, 教授 (30312846)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 生活習慣病 / エビデンス / 糖尿病 / メタボリックシンドローム / 肥満 / 動脈硬化 / 高齢者 / 危険因子 |
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| Research Abstract |
本研究は、生活習慣病の予防・治療に必須の包括的・具体的で実効性ある生活習慣改善指導を実現するために、医学・栄養学・身体活動学・統計疫学など関連分野を学際融合した上、(1)日本人を対象にした、(2)関係領域の学際融合による、(3)前向き研究に基づく科学的エビデンスを確立することを目的に開始された。この目的達成のために、若年者から高齢者まで、生活習慣病未発症者から患者まで、リスク評価から実践介入まで、を系統的に網羅する8つのサブプロジェクトを推進している。本年度はまだ初年度であるが、これらのうち、サブプロジェクト[1]各種生活習慣病の危険因子と治療法に関する定量的メタアナリシス、サブプロジェクト[4]生活習慣を考慮したより効率的な生活習慣病スクリーニングの開発、サブプロジェクト[5]生活習慣病患者における合併症予防に関わる因子の解明、を中心に実施し、幸いなことにすでに多くの成果が得られている。これらは下記のとおり、インパクトファクターが5-8程度の国際的なquality journalや米国糖尿病学会や欧州糖尿病学会などの権威ある国際学会に発表され、わが国の生活習慣病学を世界に紹介する上でも一定の寄与を成し得たと考えている。たとえば、これらのうちには、現在行われている検診や人間ドックのデータを活用して、将来糖尿病になりやすい人をできるだけ早く予測し、その後の生活習慣指導に役立てることなど、わが国の保健・医療現場ですぐに役立つエビデンス、すでに糖尿病になった人において、将来の合併症を予測する指標や食生活に関するエビデンス、飲酒の影響や果物摂取の効果など多岐にわたる。今後も引き続きこのペースを維持して、同様の手法を用いて、残りのサブプロジェクトについても順次検討を進めていく予定である。
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
前述ならびに下記リストの通り、初年度ですでに27本の英文原著論文や、20回以上の一流国際学会における発表がなされており、予想以上の効果が見られている。
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| Strategy for Future Research Activity |
予想以上に成果が上がり、論文作成や国際学会発表にかかる費用が増加している。また研究に加わりたいという院生の入学も増えている。このような、研究の予想以上の進展・拡大に伴う経費増加にどのように対応するか検討中である。
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| Expenditure Plans for the Next FY Research Funding |
上記のように、研究の予想以上の進展・拡大に伴う人的、設備的な経費増加にあたり、その対応を検討中である。
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[Journal Article] Efficacy and safety in sitagIiptin therapy for diabetes compIicated by non-aIcohol ic fatty Iiver disease2013
Author(s)
Arase Y, Kawamura Y, Seko Y, Kobayashi M, Suzuki F, Suzuki Y, Akuta N, Kobayashi M, Sezaki H, Saito S, Hosaka T, Ikeda K, Kumada H, Ohmoto-Sekine Y, Hsieh SD, Amakawa K, Ogawa K, Matsumoto N, Iwao A, Tsuji H, Hara S, Mori Y, Okubo M, Sone H, Kobayashi T
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Journal Title
Hepatol Res
Volume: 20130300(In press)
DOI
Peer Reviewed
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[Journal Article] DeveIopment of a Screening Score forllndiagnosed Diabetes and Its Application in Estimating Absolute Risk of Future Type 2 Diabetes in Japan: Toranomon Hospital Health Management Center Study 10 (TOPICS 10)2013
Author(s)
Heianza Y, Arase Y, Saito K, Hsieh SD, Tsuji H, Kodama S, Tanaka S, Ohashi Y, Shimano H, Yamada N, Hara S
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Journal Title
J CIin Endocrinol Metab
Volume: 98(3)
Pages: 1051-1060
DOI
Peer Reviewed
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[Journal Article] Fruit intake and incident diabetic retinopathy with type 2 diabetes2013
Author(s)
Tanaka S, Yoshimura Y, Kawasak i R, Kamada C, Tanaka S, Horikawa C, Ohashi Y, Araki A, I to H, Akanuma Y, Yamada N, Yamashita H, Sone H; Japan Diabetes Complications Study Group
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Journal Title
Epidemiology
Volume: 24(2)
Pages: 204-211
DOI
Peer Reviewed
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[Journal Article] Role of aIcohoI drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS 11)2013
Author(s)
Meianza Y, Arase Y, Saito K, Tsuji H, Fujihara K, Hsieh SD, Kodama S, Shimano H, Yamada N, Hara S, Sone H
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Journal Title
Am J Clin Nutr
Volume: 97(3)
Pages: 561-568
DOI
Peer Reviewed
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[Journal Article] Leisure-time physical activity is a significant predictor of stroke and total mortality in Japanese patients with type 2 diabetes: analysis from the Japan Diabetes Complications Study (JDCS)2013
Author(s)
Sone H, Tanaka S, Tanaka S, Suzuki S, Seino H, Hanyu 0, Sato A, Toyonaga T, Okita K, lshibashi S, Kodama S, Akanuma Y, Yamada N；on behalf of the Japan Diabetes CompIicat ions Study Group
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Journal Title
Diabetologia
Volume: 20130200(In perss)
DOI
Peer Reviewed
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[Journal Article] Risk of Cardiovascular Diseases Is Increased Even with Mild Diabetic Retinopathy: The Japan Diabetes Complications Study2013
Author(s)
Kawasaki R, Tanaka S, Tanaka S, Abe S, Sone H, Yokote K, Ishibashi S, Katayama S, Ohashi Y, Akanuma Y, Yamada N, Yamashita H; for the Japan Diabetes Complications Study Group
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Journal Title
Ophthalmology
Volume: 120(3)
Pages: 574-582
DOI
Peer Reviewed
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[Journal Article] Comparisons of the strength of associations with future type 2 diabetes risk among anthropometr ic obesity indicators, including waist-to-height ratio: a meta-analysis2012
Author(s)
Kodama S, Hor i kawa C, Fujihara K, Heianza Y, Hirasawa R, Yachi Y, Sugawara A, Tanaka S, Shimano H. lida KT, Saito K, Sone H
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Journal Title
Am J Epidemiol
Volume: 176(11)
Pages: 959-969
DOI
Peer Reviewed
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[Journal Article] DeveIopment of a new scoring system for predicting the 5 year incidence of type 2 diabetes in Japan: the Toranomon Hospital Health Management Center Study 6 (TOPICS 6)2012
Author(s)
Heianza Y, Arase Y, Hsieh SD, Saito K, Tsuji H, Kodama S, Tanaka S, Ohashi Y, Shimano H, Yamada N, Hara S, Sone H
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Journal Title
Diabetologia
Volume: 55(12)
Pages: 3213-3223
DOI
Peer Reviewed
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[Journal Article] Self-reported rate of eating is significantly associated with body mass index in Japanese patients with type 2 diabetes: Japan Diabetes Clinical Data Management Study Group (JDDM26)2012
Author(s)
Saito A, Kawai K, Yanagisawa M, Yokoyama H, Kuribayashi N, Sugimoto H, Oishi M, Wada T, Iwasaki K, Kanatsuka A, Yagi N, Okuguchi F, Miyazawa K, Arai K, Saito K, Sone H
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Journal Title
Appetite
Volume: 59(2)
Pages: 252-255
DOI
Peer Reviewed
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[Journal Article] Non-high-density I ipoprotein cholesterol: an important predictor of Stroke and diabetes-related mortality in Japanese elderly diabetic patits2012
Author(s)
Araki A, Iimuro S, Sakurai T, Umegaki H, Iijima K, Nakano H, Oba K, Yokono K, Sone H, Yamada N, Ako J, Kozaki K, Miura H, Kashiwagi A, Kikkawa R, Yoshimura Y, Nakano T, Ohashi Y, I to H; Japanese Elderly Intervention Trial Research Group
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Journal Title
Geriatr Gerontol Int
Volume: 12 Suppl 1
Pages: 18-28
DOI
Peer Reviewed
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[Journal Article] Long-term multiple risk factor interventions in Japanese eIderly diabetic patients: the Japanese Elderly Diabetes Intervention Trial一一study design, baseline characteristics and effects of intervention2012
Author(s)
Araki A, Iimuro S, Sakurai T, Umegaki M, I i j ima K, Nakano H, Oba K, Yokono K, Sone H, Yamada N, Ako J, Kozaki K, Miura H, Kashiwagi A, Kikkawa R, Yoshimura Y, Nakano T, Ohashi Y, I to H; Japanese Elder Iy Diabetes Intervention Trial Study Group
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Journal Title
Geriatr Gerontol Int
Volume: 12 Suppl 1
Pages: 7-17
DOI
Peer Reviewed
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[Journal Article] Screening for pre-diabetes to predict future diabetes using var ious cut-off points for HbAdc) and impaired fasting glucose: the Toranomon Hospital Health Management Center Study 4 (TOPICS 4)2012
Author(s)
Heianza Y, Arase Y, Fujihara K, Tsuji H, Saito K, Hsieh SD, Kodama S, Shimano H, Yamada N, Hara S, Sone H
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Journal Title
Diabet Med
Volume: 29(9)
Pages: e279-e285
DOI
Peer Reviewed
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[Journal Article] High normal HbA(1c) levels were associated with impaired insulin seeretion without escalating insulin resistance in Japanese individuals : the Toranomon HospitaI Health Management Center Study 8 (TOPICS 8)2012
Author(s)
Heianza Y, Arase Y, Fu j ihara K, Tsuj i H, Saito K, Hsieh SD, Kodama S, Shimano H, Yamada N, Hara S, Sone H
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Journal Title
Diabet Med
Volume: 29(10)
Pages: 1285-1290
DOI
Peer Reviewed
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[Journal Article] Chronic kidney disease categories and renal-cardiovascular outcomes in type 2 diabetes without prevalent cardiovascular disease: a prospective cohort study (JDDM25)2012
Author(s)
Yokoyama H, Araki S, Haneda M, Matsushima M, Kawai K, Hirao K, 0ishi M, Sugimoto K, Sone H, Maegawa H, Kashiwagi A; Japan Diabetes CI inical Data Management Study Group
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Journal Title
Diabetologia
Volume: 55(7)
Pages: 1911-1918
DOI
Peer Reviewed
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[Journal Article] Longitudinal trajectories of HbA1c and fasting plasma glucose levels during the deveIopment of type 2 diabetes: the Toranomon Hospital HeaIth Management Center Study 7 (TOPICS 7)2012
Author(s)
Heianza Y, Arase Y, Fuj ihara K, Hsieh SD, Saito K, Tsuj i H, Kodama S, Yahagi N, Shimano H, Yamadi N, Mara S, Sone H
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Journal Title
Diabetes Care
Volume: 35(5)
Pages: 1050-1052
DOI
Peer Reviewed
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[Journal Article] Comparison of various lipid variables as predictors of coronary heart disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study2012
Author(s)
Sone H, Tanaka S, Tanaka S, Iimuro S, Ishibashi S, 0 i kawa S, Shimano H, Katayama S, Ohash i Y, Akanuma Y, Yamada N; Japan Diabetes Complicat ions Study Group
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Journal Title
Diabetes Care
Volume: 35(5)
Pages: 1150-1157
DOI
Peer Reviewed
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[Presentation] Establishment of potent antigen presenting cell line by lentiviral vector-mediated transduction of caTLR4 gene into leukemic plasmacytoid dendritic cell line (PMDC11)2012
Author(s)
Takahashi M, Iwafuchi M, Yamahira A, Satoh N, Uchiyama T, Hashimoto S, Bonehill A, Faure-Kumar E, Bogan B, Kasahara N, Takizawa J, Sone H, Narita M
Organizer
The 12th International Symposium on Dendritic Cells (DC)
Place of Presentation
Deagu, Korea
Year and Date
2012-10-07
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[Presentation] Association between pulse pressure and cardiovascular risk in diabetes mellitus: a meta-analysis2012
Author(s)
Horikawa C, Kodama S, Heianza Y, Yoshizawa S, Fujihara K, Tanaka S, Iida K. T, Yachi Y, Ohashi Y, Sone H
Organizer
48th European Association for the Study of Diabetes
Place of Presentation
Berlin, Germany
Year and Date
2012-10-01
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[Presentation] Comparison of Framingham risk score, UKPDS risk engine, maximum-IMT, and LDL-C/HDLC ratio for predicting coronary plaque in asymptomatic patients with type 2 diabetes2012
Author(s)
Fujihara K, Suzuki H, Sato A, Kodama S, Heianza Y, Ishizu T, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yamada N, Sone H, Shimano H
Organizer
48th European Association for the Study of Diabetes
Place of Presentation
Berlin, Germany
Year and Date
2012-10-01
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[Presentation] Predictors of ischaemic heart disease and cerebrovascular attack in late elderly diabetic individuals: the roles of HDL-cholesterol and the LDL-C/HDL-C ratio2012
Author(s)
Hayashi T, Itoh H, Araki A, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Noda M, Ina K, Nomura H, Japan CDM Investigators group
Organizer
48th European Association for the Study of Diabetes
Place of Presentation
Berlin, Germany
Year and Date
2012-10-01
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[Presentation] Evelopment and evaluation of screening score for detecting undiagnosed diabetes and estimating absolute risk of future type 2 diabetes: TOPICS2012
Author(s)
Heianza y Hara S, Yoshizawa S, Kodama S, Saito K, Hsieh S. D, Horikawa C, Tsuji H, Yamada N, Arase Y, Sone H
Organizer
48th European Association for the Study of Diabetes
Place of Presentation
Berlin, Germany
Year and Date
2012-10-01
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[Presentation] Leisure-time physical activity is a significant predictor for total mortality and stroke among Japanese patients with type 2 diabetes: the Japan Diabetes Complications Study2012
Author(s)
Sone H, Tanaka S, Tanaka S, Suzuki S, Seino H, Sato A, Araki A, Ishibashi S, Ohashi Y, Akanuma Y, YamadaN
Organizer
48th European Association for the Study of Diabetes
Place of Presentation
Berlin, Germany
Year and Date
2012-10-01
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[Presentation] Comparison of current BMI histories to screen for undiagnosed diabetes in Japanese men: Toranomon Hospital Health Management Center Study2012
Author(s)
Yoshizawa S, Heianza Y, Horikawa C, Hara S, Saito K, Kodama S, Hsieh S. D, Tsuji H, Y amada N, Arase Y, Sone H
Organizer
48th European Association for the Study of Diabetes
Place of Presentation
Berlin, Germany
Year and Date
2012-10-01
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[Presentation] New Risk Score for Predicting 5-year Incidence of Typ 2 Diabetes in Japan: the Toranomon Hospital Health Management Center Study2012
Author(s)
Heianza Y, Arase Y, Tsuji H, Yoshizawa S, Saito K, Hsieh SD, Kodama S, Yamada N, Hara S, Sone H
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] A Meta-Analysis of the Quantitative Relationship between Fat Intake and Incident DM2012
Author(s)
Tajima R, Kodama S, Horikawa C, Yachi Y, Sugawara A, Heianza Y, Hirawasa R, Fujiwara K, Saito K, IIDA KT, Sone H
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Quality and accuracy of Internet information concerning a healthy diet2012
Author(s)
Hirasawa R, Sugawara A, Saito K, Kodama S, Yachi Y, Yoshizawa S, Horikawa C, Heianza Y, Ibe Y, Sone H
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Physical Activity is Associated with Lower Risk of Stroke but Not Coronary Heart Disease (CHD)in Japanese Patients with Type 2 Diabetes-Analysis of the Japan Diabetes Complications Study (JDCS)2012
Author(s)
Sone H, Tanaka S, Tanaka S, Seino H, Ishibashi S, Shimano H, Oikawa S, Katayama S, Ohashi Y, Akanuma Y, Yamada N, Japan Diabetes Complications Study Group
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Differences in relationships Between Diabetes Duration and Diabetes-related psychological distress; Japan Diabetes Clinical Data Management study2012
Author(s)
Sugawara A, Kawai K, Yuhara A, Oishi M, Sugimoto H, Yokoyama H, Yagi N, Okada A, Iwasaki K, Miyazawa K, Okuguchi F, Dake F, Saito A, Saito K, Sone H, Japan Diabetes Clinical Data Manegement Study Group
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Fruit Intake and Incident Retinopathy in Japanese Patients with Type 2 Diabetes. Nutritional Analysis in the Japan Diabetes Complications Study (JDCS)2012
Author(s)
Tanaka S, Yoshimura Y, Kawasaki R, Kamada C, Tanaka S, Horikawa C, Ohashi Y, Araki A, Ito H, Akanuma Y, Yamada N, Yamashita H, Sone H, Japan Diabetes Complications Study Group
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Low Lung F unction and Risk of Type 2 Diabetes 1n Japanese men: the Toranomon Hospital Health Management Center Study2012
Author(s)
Heianza Y, Arase y Tsuji H, Sugawara A, Saito K, Hsieh SD, Amakawa K, Kodama S, Yamada N, Hara S, Sone H
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Prediction of incident diabetes by measurements of both HbAlC and fasting plasma glucose in comparison with use of HbAlc or FPG alone-a meta-analysis2012
Author(s)
Kodama S, Horikawa C, Tajima R, Fujihara K, Yoshizawa S, Ibe Y, Hirasawa R, Shimano H, Saito K, Sone H
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Both lifetime maximum BMI and BMI change since age 20 years to maximum were strongly associated with having undiagnosed diabetes in Japanese2012
Author(s)
Yoshizawa S, Heianza Y, Arase Y, Tsuji H, Saito K, Hsieh SD, Kodama S, Yamada N, Hara S, Sone H
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Determining Optimal Combined Thresholds of HbAlc and Fasting Plasma Glucose as Predictors of Type 2 Diabetes: the Toranomon Hospital Health Management Center Study2012
Author(s)
Sugawara A, Heianza Y, Arase Y, Fujihara K, Tsuji H, Saito K, Hsieh SD, Kodama S, Yamada N, Hara S, Sone H
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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[Presentation] Relationship between obstructive sleep apnea and diabetes risk- A meta-analysis2012
Author(s)
Fujihara K, Kodama S, Horikawa C, Heianza Y, Sugawara A, Maki M, Yachi Y, Shimano H, Saito K, Sone H
Organizer
72nd American Diabetes Association Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-11
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