健康科学と臨床医学を統合した日本人における生活習慣病の予防・治療のエビデンス確立

2014 Fiscal Year Annual Research Report

• Project/Area Number: 24300233
• Research Institution: Niigata University
• Principal Investigator: 曽根 博仁 新潟大学, 医歯学系, 教授 (30312846)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 生活習慣病 / エビデンス / 肥満 / 糖尿病 / 動脈硬化

Outline of Annual Research Achievements

すでに世界一の長寿を達成したわが国の次の目標は、健康寿命の延伸である。その最大の障害となる生活習慣病の予防・治療には生活習慣改善が必須であるが、現場では実効性ある生活習慣指導が十分なされていない。本研究は、生活習慣病の予防・治療に実効性のある包括的・具体的な生活習慣改善指導を実現するため、医学・栄養学・身体活動学・統計疫学など関連分野を学際融合し、①日本人を対象にした、②関係領域の学際融合による、③前向き研究に基づく、科学的エビデンスを確立することを目的としている。そのため、若年者から高齢者、生活習慣病未発症者から患者、リスク評価から実践介入を系統的に網羅する8つのサブプロジェクトを推進してきた。これまでこれらのうち、 [1] 各種生活習慣病の危険因子と治療法に関する定量的メタアナリシス、[2] 若年者における運動習慣の効用に関するコホート研究、[3] 若年者における食習慣の影響に関するコホート研究、[4]生活習慣を考慮したより効率的な生活習慣病スクリーニング法の開発、[5]生活習慣病患者における合併症予防に関わる因子の解明、[6] 高齢者の健康寿命延伸のための生活習慣改善エビデンスの確立、[7] 生活習慣・健康科学情報リテラシー確立のための方策の検討、については、多くの国際誌掲載論文や国際学会発表などが得られ、わが国の生活習慣病学の発展に寄与することができた。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

前述ならびに下記リストの通り、前年度に引き続き昨年度も36本の英文原著論文を含む80本以上の論文・著書・総説や、30回近い国際学会における発表がなされており、予想以上の効果が見られている。最終年度もこのペースを維持して、世界中の生活習慣病予防・治療の現場に有用なエビデンス確立に努めていく予定である。

Strategy for Future Research Activity

上記のとおり、これまでサブプロジェクト[1]～[7]については予定通り順調に終了し、一定の成果を上げてきたので、最終年度の今年度においては今年度はこれらをさらに深化発展させた上、それらのまとめとして、[1]～[7]を統括した生活習慣改善のエビデンスに関する統合データベースの構築を行う予定である。これまで国際学会ならびに学会誌に多くの成果を発表できたが、さらに一般の人にもわかりやすい形にして公開する予定である。

Causes of Carryover

研究が事前に想定していたより効率よく進み、より少ないデータベースから効率的に多くの成果がでるようになり、さらに作業を担当させている大学院生達も論文執筆の能力が研究期間中に大幅に向上した結果、英文校正委託などにかかる費用を予定より大幅に節約することができたため。また国際学会についてもお互い手分けして、少人数の出席者で多くの演題を発表できるように工夫したため、出張費用も節約できたため。

Expenditure Plan for Carryover Budget

上記で節約できた費用を最大限に活用して、本年度に新たな測定機器（国際的に研究に汎用されている体脂肪計）を購入し、これによって既存の被験者のデータを追加することにより、本研究をさらに拡張・発展させ、さらに大きな成果を上げるために使用することにした。

Research Products

• [Journal Article] A case of hypoglycemia attributable to atypical antipsychotic drugs (2015)
  • Author(s): Ishiguro H, Hnyu O, Houya S, Morohashi K, Kuroiwa G, Kuwabara O, Nakamaru T, Fuse K, Sato K, Sone H
  • Journal Title: Diabetol Int. Volume: 6 Pages: 341-346
  • DOI: 10.1007/s13340-015-0203-5
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 医療ビッグデータ時代の科学的根拠に基づく糖尿病・生活習慣病対策－「オール新潟」体制の可能性－ (2015)
  • Author(s): 曽根博仁
  • Journal Title: 陽光 Volume: 11 Pages: 1-3
• [Journal Article] 糖尿病とストレス-解消法を考える 講義篇 (2015)
  • Author(s): 松永佐澄志、曽根博仁
  • Journal Title: べんちのーと Volume: 25 Pages: 16-17
• [Journal Article] 大規模臨床研究からみた肥満と2型糖尿病の関係 (2015)
  • Author(s): 松永佐澄志、曽根博仁
  • Journal Title: The Lipid Volume: 26 Pages: 51-56
• [Journal Article] 糖尿病と糖尿病網膜症の疫学 (2015)
  • Author(s): 曽根博仁、川崎良、山下英俊
  • Journal Title: あたらしい眼科 Volume: 32 Pages: 313-319
• [Journal Article] BMIと高血圧: TOPICS 18 (2015)
  • Author(s): 平安座依子、曽根博仁
  • Journal Title: 血圧 Volume: 22 Pages: 6-7
• [Journal Article] 糖尿病三大合併症 (2015)
  • Author(s): 金子正儀、羽入修、曽根博仁
  • Journal Title: 臨床雑誌 内科 Volume: 115 Pages: 621-626
• [Journal Article] 妊婦の糖代謝異常 (2015)
  • Author(s): 谷内洋子、曽根博仁
  • Journal Title: Bios Volume: 20 Pages: 3-6
• [Journal Article] 肥満と2型糖尿病～わが国における動向～ (2015)
  • Author(s): 植村靖行、平安座依子、児玉暁、曽根博仁
  • Journal Title: Diabetes Frontier Volume: 26 Pages: 20-26
• [Journal Article] 糖尿病合併症の疫学－わが国の2型糖尿病患者データを中心に (2015)
  • Author(s): 曽根博仁
  • Journal Title: 医学のあゆみ Volume: 252 Pages: 355-361
• [Journal Article] Circulating malondialdehyde-modified LDL-related variables and coronary artery stenosis in asymptomatic patients with type 2 diabetes. (2015)
  • Author(s): Fujihara K, Suzuki H, Sato A, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Yagyu H, Sone H, Shimano H
  • Journal Title: J Diabet Res Volume: - Pages: -
  • DOI: 10.1155/2015/507245
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trajectory of Body Mass Index Before the Development of Type 2 Diabetes in Japanese Men: Toranomon Hospital Health Management Center Study 15 (TOPICS 15) (2015)
  • Author(s): Heianza Y, Arase Y, Kodama S, Tsuji H, Tanaka S, Saito K, Hara S, Sone H
  • Journal Title: J Diabet Invest Volume: - Pages: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Correlation between SNP genotypes and periodontitis in Japanese type II diabetic patients: a preliminary study (2015)
  • Author(s): Damrongrungruang T, Ogawa H, Hori-Matsumoto S, Minagawa K, Hanyu O, Sone H, Miyazaki H
  • Journal Title: Odontology Volume: - Pages: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fasting glucose and HbA1c levels as risk factors for the development of hypertension in Japanese individuals: Toranomon hospital health management center study 16 (TOPICS 16) (2015)
  • Author(s): Heianza Y, Arase Y, Kodama S, Hsieh SD, Tsuji H, Saito K, Hara S, Sone H
  • Journal Title: J Hum Hypertens Volume: 29 Pages: 254-9
  • DOI: 10.1038/jhh.2014.77.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Simple Self-Reported Behavioral or Psychological Characteristics as Risk Factors for Future Type 2 Diabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 14 (2015)
  • Author(s): Heiaza Y, Arase Y, Kodama S, Tsuji H, Fujihara K, Saito K, Hara S, Sone H
  • Journal Title: J Diabet Invest Volume: 6 Pages: 236-41
  • DOI: 10.1111/jdi.12274.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Risk of the Development of Type 2 Diabetes in Relation to Overall Obesity, Abdominal Obesity and the Clustering of Metabolic Abnormalities in Japanese Individuals - Does Metabolically Healthy Overweight Really Exist?: Niigata Wellness Study (2015)
  • Author(s): Heianza Y, Kato K, Kodama S, Ohara N, Suzuki A, Tanaka S, Hanyu O, Sato K, Sone H
  • Journal Title: Diabet Med Volume: 32 Pages: 665-72
  • DOI: 10.1111/dme.12646.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The combination of elevated triglycerides and abnormal fasting glucose increases risk of cerebral infarction in patients with mild to moderate hypercholesterolemia: A post hoc analysis of the MEGA study (2015)
  • Author(s): Nakagami T, Nishimura R, Sone H, Tajima N
  • Journal Title: J Cardiovasc Pharmacol Ther Volume: 20 Pages: 169-73
  • DOI: 10.1177/1074248414537706
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Potential impact of joint association of alanine aminotransferase and gamma- glutamyltransferase on insulin resistance in Japan: the Toranomon Hospital Health Management Center Study 19 (TOPICS 19) (2015)
  • Author(s): Arase Y, Heianza Y, Hara S, Ohmoto-Sekine Y, Amakawa K, Tsuji H, Ogawa K, Saito K, Kodama S, Ikeda K, Kumada H, Kobayashi T, Sone H
  • Journal Title: Hepatol Res Volume: 45 Pages: 247-58
  • DOI: 10.1111/hepr.12343.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The factors that affect exercise therapy for patients with type 2 diabetes in Japan: a nationwide survey (2015)
  • Author(s): Arakawa S, Watanabe T, Sone H, Tamura Y, Kobayashi M, Kawamori R, Atsumi Y, Oshida Y, Tanaka S, Suzuki S, Makita S, Ohsawa I, Sato Y
  • Journal Title: Diabetol Int Volume: 6 Pages: 19-25
  • DOI: 10.1007/s13340-014-0166-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact on short-term glycaemic control of initiating diabetes care versus leaving diabetes untreated among individuals with newly screening-detected diabetes in Japan (2014)
  • Author(s): Heianza Y, Suzuki A, Fujihara K, Tanaka S, Kodama S, Hanyu O, Sone H
  • Journal Title: J Epidemiol Community Health Volume: 68 Pages: 1189-95
  • DOI: 10.1136/jech-2014-204054.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study (2014)
  • Author(s): Fujihara K, Sugawara A, Heianza Y, Sairenchi T, Irie F, Iso H, Doi M, Shimano H, Watanabe H, Sone H, Ota H
  • Journal Title: J Atheroscler Thromb Volume: 21 Pages: 1152-69
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combination effect of hypertension and diabetes mellitus on urinary protein excretion: Response to Dr Kawada (2014)
  • Author(s): Ohara N, Hanyu O, Sone H
  • Journal Title: J Hypertens Volume: 32 Pages: 2278
  • DOI: 10.1097/HJH.0000000000000353.
  • Peer Reviewed
• [Journal Article] Stability and changes in metabolically healthy overweight or obesity and risk of future diabetes: Niigata wellness study (2014)
  • Author(s): Heianza Y, Kato K, Kodama S, Suzuki A, Tanaka S, Hanyu O, Sato K, Sone H
  • Journal Title: Obesity Volume: 22 Pages: 2420-5
  • DOI: 10.1002/oby.20855.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Role of sleep duration as a risk factor for Type 2 diabetes among adults of different ages in Japan: the Niigata Wellness Study (2014)
  • Author(s): Heianza Y, Kato K, Fujihara K, Tanaka S, Kodama S, Hanyu O, Sato K, Sone H
  • Journal Title: Diabet Med Volume: 31 Pages: 1363-7
  • DOI: 10.1111/dme.12555.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75years among 4014 type 2 diabetic individuals (2014)
  • Author(s): Hayashi T, Kubota K, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Araki A, Noda M, Noto H, Sakuma I, Yoshizumi M, Ina K, Nomura H, on behalf of Japan CDM group
  • Journal Title: Int J Cardiol Volume: 177 Pages: 860-6
  • DOI: 10.1016/j.ijcard.2014.10.093.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dietary Sodium Intake and Incidence of Diabetes Complications in Japanese Patients with Type 2 Diabetes: Analysis of the Japan Diabetes Complications Study (JDCS) (2014)
  • Author(s): Horiakwa C, Yoshimura Y, Kamada C, Tanaka S, Tanaka S, Hanyu O, Araki A, Ito H, Tanaka A, Ohashi Y, Akanuma Y, Yamada N, Sone H
  • Journal Title: J Clin Endocrinol Metab Volume: 99 Pages: 3635-43
  • DOI: 10.1210/jc.2013-4315.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Utility of triglycerides for predicting incident diabetes mellitus according to fasting status and body mass index category: Ibaraki Prefectural Health Study (2014)
  • Author(s): Fujihara K, Sugawara A, Heianza Y, Sairenchi T, Irie F, Iso H, Doi M, Shimano H, Watanabe H, Sone H, OtaH
  • Journal Title: J Atheroscler Thromb Volume: 21 Pages: 1152-69
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of Helicobacter Pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-analysis (2014)
  • Author(s): Horikawa C, Kodama S, Fujihara K, Yachi Y, Tanaka S, Suzuki A, Hanyu O, Shimano H, Sone H
  • Journal Title: J Diab Res Volume: - Pages: -
  • DOI: 10.1155/2014/250620.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of Body Mass Index History in Predicting Risk of the Development of Hypertension in Japanese Individuals: Toranomon Hospital Health Management Center Study 18 (TOPICS 18) (2014)
  • Author(s): Heianza Y, Kodama S, Arase Y, Hsiesh SD, Yoshizawa S, Tsuji H, Saito K, Tanaka S, Hara S, Sone H
  • Journal Title: Hypertension Volume: 64 Pages: 247-52
  • DOI: 10.1161/HYPERTENSIONAHA.113.02918.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of different aspects of BMI History to Identify Undiagnosed Diabetes in Japanese Men and Women: Toranomon Hospital Health Management Center Study 12 (TOPICS 12) (2014)
  • Author(s): Yosizawa S, Heianza Y, Arase Y, Saito K, Hsieh SD, Tsuji H, Hanyu O, Suzuki A, Tanaka S, Kodama S, Shimano H, Hara S, Sone H
  • Journal Title: Diabetic Med Volume: 31 Pages: 1378-86
  • DOI: 10.1111/dme.12471.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship between a low ankle brachial index to all-cause death and cardiovascular events in subjects with and without diabetes (2014)
  • Author(s): Yokoyama H, Sone H, Honjo J, Okizaki S, Yamada D, Shudo R, Shimizu H, Moriya T, Haneda M
  • Journal Title: J Atheroscl. Thromb Volume: 21 Pages: 574-81
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Importance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events (2014)
  • Author(s): Ina K, Hayashi T, Araki A, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Kubota K, Noda M, Noto H, Ding QF, Zhang J, Yu ZY, Yoon BK, Nomura H, Kuzuya M; Japan CDM Group
  • Journal Title: Geriatr Gerontol Int Volume: 14 Pages: 806-10
  • DOI: 10.1111/ggi.12168.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reversible brain atrophy and cognitive impairment in an adolescent Japanese patient with primary adrenal Cushing's syndrome (2014)
  • Author(s): Ohara N, Suzuki H, Suzuki A, Kaneko M, Ishizawa M, Furukawa K, Abe T, Matsubayashi Y, Yamada T, Hanyu O, Shinohata T, Sone H
  • Journal Title: Neuropsychiatr Dis Treat Volume: 10 Pages: 1763-7
  • DOI: 10.2147/NDT.S70611.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Second trimester postload glucose level as an important predictor of low birth weight infants: Tanaka Women's Clinic Study (2014)
  • Author(s): Yachi Y, Tanaka Y, Nishibata I, Yoshizawa S, Fujihara K, Kodama S, Suzuki A, Hanyu O, Sone H
  • Journal Title: Diabetes Res Clin Pract Volume: 105 Pages: e16-9
  • DOI: 10.1016/j.diabres.2014.02.006.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Manifestations of Fulminant CD8 T-cell Post-transplant Lymphoproliferative Disorder Following the Administration of Rituximab for Lymphadenopathy with a High Level of Epstein-Barr Virus (EBV) Replication after Allogeneic Hematopoietic Stem Cell Transplantation (2014)
  • Author(s): Tanaka T, Takizawa J, Miyakoshi S, Kozakai T, Fuse K, Shibasaki Y, Moriyama M, Ohshima K, Toba K, FurukawaT, Sone H, Masuko M
  • Journal Title: Intern Med Volume: 53 Pages: 2115-19
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] High Risk of Failing Eradication of Helicobacter Pylori in Patients with Diabetes: A Meta-analysis (2014)
  • Author(s): Horikawa C, Kodama S, Fujihara K, Hirasawa R, Yachi Y, Suzuki A, Hanyu O, Shimano H, Sone H
  • Journal Title: Diabet Res Clin Prac Volume: 106 Pages: 81-7
  • DOI: 10.1016/j.diabres.2014.07.009.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Commentary on the UKPDS outcomes model 2: Need for long-term follow-up and quality of life data in Asian patients (2014)
  • Author(s): Tanaka S, Tanaka S, Sone H
  • Journal Title: J Diabet Invest Volume: 5 Pages: 281-3
  • DOI: 10.1111/jdi.12207.
  • Peer Reviewed / Open Access
• [Journal Article] Metabolically Healthy Obesity, Presence or Absence of Fatty Liver, and Risk of Type 2 Diabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20) (2014)
  • Author(s): Heianza Y, Arase Y, Tsuji H, Fujihara K, Saito K, Hsieh SD, Tanaka S, Kodama S, Hara S, Sone H
  • Journal Title: J Clin Endocrinol Metab Volume: 99 Pages: 2952-60
  • DOI: 10.1210/jc.2013-4427.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study Existing Cohorts Combined (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes (2014)
  • Author(s): Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H
  • Journal Title: J Atheroscl. Thromb Volume: 21 Pages: 799-815
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cohort Profile: The Japan Diabetes Complications Study: a long-term follow-up of a randomised lifestyle intervention study of type 2 diabetes (2014)
  • Author(s): Tanaka S, Tanaka S, Iimuro S, Yamashita H, Katayama S, Ohashi Y, Akanuma Y, Yamada N, Sone H, Japan Diabetes Complications Study Group
  • Journal Title: Int J Epidemiol Volume: 43 Pages: 1054-62
  • DOI: 10.1093/ije/dyt057.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Food Groups and Weight Gain in Japanese Men (2014)
  • Author(s): Ibe Y, Takahashi Y, Sone H
  • Journal Title: Clin Obes Volume: 4 Pages: 157-64
  • DOI: 10.1111/cob.12056.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Response to Comment on Heianza et al. Effect of Postmenopausal Status and Age at Menopause on Type 2 Diabetes and Prediabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17) (2014)
  • Author(s): Heianza Y, Sone H
  • Journal Title: Diabetes Care Volume: 37 Pages: e165-6
  • DOI: 10.2337/dc14-0745.
  • Peer Reviewed
• [Journal Article] Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study (2014)
  • Author(s): Horikawa C, Yoshimura Y, Kamada C, Tanaka S, Tanaka S, Takahashi A, Hanyu O, Araki A, Ito H, TanakaA, Ohashi Y, Akanuma Y, Yamada N, Sone H
  • Journal Title: J Diabet Invest Volume: 5 Pages: 176-87
  • DOI: 10.1111/jdi.12146.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Quantitative relationship between body weight gain in adulthood and incident type 2 diabetes: a meta-analysis (2014)
  • Author(s): Kodama S, Horikawa C, Fujihara K, Yoshizawa S, Yachi Y, Tanaka S, Ohara N, Matsunaga S, Yamada T, Hanyu O, Sone H
  • Journal Title: Obes Rev Volume: 15 Pages: 202-14
  • DOI: 10.1111/obr.12129.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 糖尿病運動療法の実行・継続率を高めるには～メッツ表を活用した運動処方の提案～ (2014)
  • Author(s): 曽根博仁
  • Journal Title: Astellas Square Volume: 12-1 Pages: 18-20
• [Journal Article] 日本人2型糖尿病における顕性アルブミン尿発症と腎機能低下に対する糖尿病網膜症および微量アルブミン尿の影響―JDCSサブ解析から― (2014)
  • Author(s): 守屋 達美, 川崎 良, 曽根 博仁, 山下 英俊, 片山 茂裕
  • Journal Title: 内科学会誌 Volume: 103 Pages: 987-93
• [Journal Article] 糖尿病とエネルギー･栄養素との関係 (2014)
  • Author(s): 広瀬歩美、曽根博仁
  • Journal Title: 日本栄養士雑誌 Volume: 57 Pages: 5-8
• [Journal Article] 運動療法の潜在パワーを見直そう (2014)
  • Author(s): 曽根博仁
  • Journal Title: DITN Volume: 439 Pages: 1
• [Journal Article] 糖尿病合併症-横断的な情報と個別診療への応用 (2014)
  • Author(s): 曽根博仁
  • Journal Title: DM Network Volume: 2 Pages: 2
• [Journal Article] 運動療法と大血管障害との関連は？ (2014)
  • Author(s): 曽根博仁
  • Journal Title: EYE-DIA Volume: 2 Pages: 7
• [Journal Article] 日本人2型糖尿病患者の病態と実態－JDCSの結果を中心に－ (2014)
  • Author(s): 曽根博仁
  • Journal Title: 診断と治療 Volume: 102 Pages: 1279-88
• [Journal Article] α-グルコシダーゼ阻害薬 (2014)
  • Author(s): 藤原和哉、曽根博仁
  • Journal Title: Pharma Media Volume: 32 Pages: 27-32
• [Journal Article] 境界型糖尿病の診断と治療管理 (2014)
  • Author(s): 曽根博仁
  • Journal Title: 月間糖尿病 Volume: 6 Pages: 7
• [Journal Article] 健診データを活かした糖尿病早期診断と発症予測 (2014)
  • Author(s): 平安座依子、曽根博仁
  • Journal Title: 月刊糖尿病 Volume: 6 Pages: 30-7
• [Journal Article] 大規模臨床研究のエビデンスに基づく糖尿病療養指導と将来 (2014)
  • Author(s): 由澤咲子、長谷川美代、曽根博仁
  • Journal Title: 臨床栄養 Volume: 125 Pages: 195-200
• [Journal Article] DPP-4阻害薬による脳卒中予防効果 (2014)
  • Author(s): 小原伸雅、曽根博仁
  • Journal Title: 分子脳血管病 Volume: 13 Pages: 27-32
• [Journal Article] Metabolically obese normal-weight (MONW) とmetabolically healthy obese (MHO)の概念と臨床的意義 (2014)
  • Author(s): 小原伸雅、平安座依子、曽根博仁
  • Journal Title: 日本臨牀 Volume: 72 Suppl4 Pages: 697-702
• [Journal Article] 積極的に運動に取り組む患者で死亡率半減 (2014)
  • Author(s): 曽根博仁
  • Journal Title: Medical Tribune Volume: Special Issue Pages: si-20
• [Journal Article] 糖尿病透析予防指導におけるチーム医療のあり方 (2014)
  • Author(s): 曽根博仁
  • Journal Title: 新潟県糖尿病療養指導士ネットワーク会会報誌 ステップ通信 Volume: 9 Pages: 1
• [Journal Article] 難聴と糖尿病 (2014)
  • Author(s): 堀川千嘉、曽根博仁
  • Journal Title: 月刊糖尿病ライフ さかえ Volume: 54 Pages: 7-12
• [Journal Article] 糖尿病運動療法の驚くべき可能性 (2014)
  • Author(s): 曽根博仁
  • Journal Title: Medical Practice Volume: 31 Pages: 835
• [Journal Article] 大血管障害のリスクファクターとしての低血糖 (2014)
  • Author(s): 松林泰弘、曽根博仁
  • Journal Title: Diabetes Frontier Volume: 25 Pages: 421-7
• [Journal Article] 狭心症, 心筋梗塞, 無痛性心筋梗塞 (2014)
  • Author(s): 鈴木裕美、曽根博仁
  • Journal Title: 糖尿病診療マスター Volume: 12 Pages: 282-5
• [Journal Article] 糖尿病患者における運動療法のエビデンス (2014)
  • Author(s): 曽根博仁
  • Journal Title: Diabetes Journal Volume: 42 Pages: 7-13
• [Journal Article] 日本人の大規模臨床エビデンスに基づく糖尿病の予防と治療－実地医家の役割を含めて－ (2014)
  • Author(s): 曽根博仁
  • Journal Title: TCS News Volume: 58 Pages: 1-2
• [Journal Article] 日本人の心血管疾患に糖尿病はどの程度影響しているのか？ (2014)
  • Author(s): 阿部孝洋、曽根博仁
  • Journal Title: Heart View. Volume: 18 Pages: 358-67
• [Journal Article] 糖尿病大血管症の予防・治療を目指した新しい治療戦略 (2014)
  • Author(s): 曽根博仁
  • Journal Title: 糖尿病合併症 Volume: 28 Pages: 59-65
• [Presentation] 糖尿病予防・治療に関する大規模臨床研究. レクチャーBL-1-8 (2015)
  • Author(s): 曽根博仁
  • Organizer: 第49回糖尿病学の進歩
  • Place of Presentation: 岡山
  • Year and Date: 2015-02-20 – 2015-02-21
  • Invited
• [Presentation] 運動の生活習慣予防・治療における効果と意義. シンポジウム3 (2014)
  • Author(s): 曽根博仁
  • Organizer: 第21回日本未病システム学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-01 – 2014-11-02
  • Invited
• [Presentation] 市民公開講座「糖尿病とその合併症の根治を目指して」～今日から始めよう、できることから～ (2014)
  • Author(s): 曽根博仁、山下茂雄、大橋優美子、幣憲一郎
  • Organizer: 第29回糖尿病合併症学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-03 – 2014-10-04
  • Invited
• [Presentation] シンポジウム 糖尿病合併症とEBM. JDCS (2014)
  • Author(s): 曽根博仁
  • Organizer: 第29回糖尿病合併症学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-03 – 2014-10-04
  • Invited
• [Presentation] Characteristics of diabetic complications in Japanese patients. (2014)
  • Author(s): Sone H
  • Organizer: 50th European Association for the Study of Diabetes
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-09-15 – 2014-09-19
  • Invited
• [Presentation] Characteristics of patients with type 2 diabetes who achieved better glycemic control through resistance training: A meta-analysis. (2014)
  • Author(s): Ishiguro H, Kodama S, Mtsunaga S, Horikawa C, Heianza Y, Ohara N, Yamada T, Suzuki T, Hanyu O, Sone H
  • Organizer: 50th European Association for the Study of Diabetes
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-09-15 – 2014-09-19
• [Presentation] Metabolically Healthy Obesity, Presence or Absence of Fatty Liver, and Risk of Type 2 Diabetes in Japanese Individuals (2014)
  • Author(s): Heianza Y, Arase Y, Tsuji H, Fujihara K, Saito K, Hsieh SD, Tanaka S, Kodama S, Hara S, Sone H
  • Organizer: 50th European Association for the Study of Diabetes
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-09-15 – 2014-09-19
• [Presentation] シンポジウム「新たな食事摂取基準2015」 糖尿病・代謝疾患 (2014)
  • Author(s): 曽根博仁
  • Organizer: 第61回日本栄養改善学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-20 – 2014-08-22
  • Invited
• [Presentation] Type 2 diabetes mellitus in East and the West and effects of lifestyle intervention. (2014)
  • Author(s): Sone H
  • Organizer: Lecture at The National University of Malaysia
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2014-06-24 – 2014-06-24
  • Invited
• [Presentation] 糖尿病の最新治療ー薬物療法を含めてー (2014)
  • Author(s): 曽根博仁
  • Organizer: 新潟薬科大学薬剤師生涯教育講座
  • Place of Presentation: 新潟
  • Year and Date: 2014-06-20 – 2014-06-20
  • Invited
• [Presentation] Limitation of Risk Value in Persons at Genetically High Risk of Diabetes mellitus-Meta-analytic Research. (2014)
  • Author(s): Kodama S, Horikawa C, Fujihara K, Heianza Y, Yachi Y, Tanaka S, Ohara N, Suzuki A, Hanyu O, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Comprehensive Analysis of Patterns of First-Line Medication for Patients with Diabetes in Japan: Nationwide Claims Database Study. (2014)
  • Author(s): Suzuki A, Heianza Y, Suzuki T, Kitazawa M, Abe T, Uemura Y, Matsunaga S, Minagawa S, Yamada T, Hanyu O, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Resistance Exercise Was Effective in Improving Glycemic Control but Inferior to Aerobic Exercise for Patients with Type 2 Diabetes Mellitus - A Meta-analysis. (2014)
  • Author(s): Ishiguro H, Kodama S, Horikawa C, Suzuki H, Matsunaga S, Heianza Y, Yamada T, Suzuki A, Hanyu O, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Risk of Development of Type 2 Diabetes by Overall Obesity, Abdominal Obesity, and Metabolic Abnormalities_Does Metabolically Healthy Obesity Really Exist? (2014)
  • Author(s): Heianza Y, Kato K, Suzuki A, Horikawa C, Matsunaga S, Yoshizawa S, Hanyu O, Kodama S, Sato K, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] High Serum Uric Acid Level Is More Predictive of Risk of Future Type 2 Diabetes in Nonobese Than in Overweight/Obese People: The Niigata Wellness Study. (2014)
  • Author(s): Matsunaga S, Heianza Y, Suzuki T, Kitazawa M, Minagawa S, Yamada T, Suzuki A, Hanyu O, Kato K, Sato K, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Nonfasting Plasma Glucose Concentration and Prediction of Future Risk of Diabetes Mellitus: The Sado Cohort Study. (2014)
  • Author(s): Tanabe N, Yamamoto M, Momotsu T, Suzuki K, Sanpei K, Tsuji T, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Diabetes Risk Related to Carrying 1 Risk Allele of a Diabetes-Susceptible Gene Is Comparable to That Related to 1 Unit of Increased Body Mass Index: A Meta-analysis. (2014)
  • Author(s): Horikawa C, Kodama S, Matsunaga S, Yoshizawa S, Heiznza Y, Yachi Y, Ohara N, Suzuki A, Hanyu O, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Magnitude of Risk of Diabetes Mellitus in Relation to Carrying Risk Alleles of Diabetes-Susceptible Genes Was Not Influenced by Covariates: A Meta-analysis. (2014)
  • Author(s): Ishiguro H, Kodama S, Horikawa C, Furukawa K, Suzuki H, Fujihara K, Heianza Y, Suzuki A, Hanyu O, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Predictive Value of Combined Single Nucleotide Polymorphisms for Diabetes Mellitus - A Meta-analysis. (2014)
  • Author(s): Kodama S, Horikawa C, Matsunaga S, Fujihara K, Heianza Y, Hirose A, Yamada T, Suzuki A, Hanyu O, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Relationship between Clinical Characteristics and Vegetable Intake in Japanese Patients with Type 2 Diabetes: Analysis from Japan Diabetes Complications Study. (2014)
  • Author(s): Horikawa C, Kamada C, Okumura R, Tanaka S, Tanaka S, Ohashi Y, Araki A, Ito H, Yoshimura Y, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Stability and Changes in the Metabolically Healthy Overweight or Obese State and the Risk of Development of Future Type 2 Diabetes. (2014)
  • Author(s): Heianza Y, Suzuki A, Kato K, Fujihara K, Yamada T, Hanyu O, Kodama S, Sato K, Sone H
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] シンポジウム 新医学へと展開する.疫学・統計学. 抗加齢医学における実例と今後. 運動による健康長寿の可能性ー臨床疫学の視点からー (2014)
  • Author(s): 曽根博仁
  • Organizer: 第14回日本抗加齢医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-06 – 2014-06-08
  • Invited
• [Presentation] ランチョンセミナー 日本人の大規模臨床エビデンスに基づく糖尿病の治療と予防～特に食事・運動療法を中心に～ (2014)
  • Author(s): 曽根博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
  • Invited
• [Presentation] シンポジウム JDCS (2014)
  • Author(s): 曽根博仁、赤沼安夫、山田信博
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
  • Invited
• [Presentation] 農村地域における糖尿病とその合併症予防のあり方 (2014)
  • Author(s): 曽根博仁
  • Organizer: 日本農村医学会新潟地方会第64回例会
  • Place of Presentation: 長岡
  • Year and Date: 2014-04-19 – 2014-04-19
  • Invited
• [Book] 増刊レジデントノート 糖尿病診療でみんなが困る疑問を集めました。血糖コントロールがうまくいくコツ (2015)
  • Author(s): 松林泰弘、曽根博仁
  • Total Pages: 245
  • Publisher: 羊土社
• [Book] 新スタンダード栄養・食物シリーズ4 疾病の成り立ち (2015)
  • Author(s): 曽根博仁
  • Total Pages: 346
  • Publisher: 東京化学同人
• [Book] 新体系 看護学全書 人体の構造と機能② 栄養生化学 (2014)
  • Author(s): 曽根博仁
  • Total Pages: 324
  • Publisher: メヂカルフレンド社
• [Book] 日本糖尿病学会編：糖尿病専門医研修ガイドブック (2014)
  • Author(s): 五十嵐智雄、曽根博仁
  • Total Pages: 514
  • Publisher: 診断と治療社
• [Book] はじめて学ぶ健康・スポーツ科学シリーズ8 スポーツ医学【内科】 (2014)
  • Author(s): 児玉暁、曽根博仁
  • Total Pages: 217
  • Publisher: 化学同人
• [Book] 糖尿病の最新食事療法のなぜに答える 基礎編 (2014)
  • Author(s): 鈴木浩史、曽根博仁
  • Total Pages: 124
  • Publisher: 医歯薬出版株式会社
• [Book] メディカルフィットネスQ&A (2014)
  • Author(s): 平安座依子、松林泰弘、藤原和哉、児玉暁、曽根博仁
  • Total Pages: 242
  • Publisher: 社会保険研究所
• [Book] Global Health Perspectives in Prediabetes and Diabetes Prevention (2014)
  • Author(s): Sone H
  • Total Pages: 500
  • Publisher: World Scientific
• [Remarks] 新潟大学医学部 血液・内分泌・代謝内科
  • URL: http://www.med.niigata-u.ac.jp/emh/