2014 Fiscal Year Final Research Report
Studies for evaluation of effects of low-dose irradiation on higher brain and autonomic nervous activities in vertebrate development
Project/Area Number |
24310039
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | The University of Tokyo |
Principal Investigator |
ODA Shoji 東京大学, 新領域創成科学研究科, 准教授 (50266714)
|
Co-Investigator(Kenkyū-buntansha) |
HISATSUNE Tatsuhiro 東京大学, 大学院新領域創成科学研究科, 准教授 (10238298)
|
Co-Investigator(Renkei-kenkyūsha) |
MITANI Hiroshi 東京大学, 大学院新領域創成科学研究科, 教授 (70181922)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 放射線被ばく / メダカ / マウス / 自律神経 / 心拍 / 高次脳機能 / 遊泳軌跡 / 低線量 |
Outline of Final Research Achievements |
Restriction of adult medaka with anesthesia befor irradiation decreased medaka's heart rate much more than sub-lethal dose irradiation of carbon ion beam, indicating that the effects of low dose irradiation upon the autonomic nervous activity regulating heart beating in medaka are very little and can be ignored. Effects by chronic irradiation is not examined and must be addressed in future. Irradiation of mouse head with high-dose gamma rays (10 Gy) induced transient cognitive impairment. The methods to digitalize tracks of swimming adults and fries of medaka and the protocols to irradiate medaka chronically with ultra-low dose rate (about 2 microSv/hour) have been established in this study, however, the planed low- and ultra-low irradiation experiments on medaka has not conducted yet and remained to be our task in near future.
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Free Research Field |
放射線生物学
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