Re-direction of the differentiation status by a novel protein transduction system LENA

2014 Fiscal Year Final Research Report

• Project/Area Number: 24310146
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Medical genome science
• Research Institution: National Hospital Organization Nagoya Medical Center (2014); Osaka Prefectural Institute of Public Health (2012-2013)
• Principal Investigator: KOMANO Atsushi 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他 (60356251)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Satoshi 国立感染症研究所, エイズ研究センター, 研究員 (50396959)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 移植•再生医療 / バイオテクノロジー / レンチウイルス様ナノ粒子 / 脱分化法 / ナノバイオ

Outline of Final Research Achievements

For the establishment of safe re-direction protocol, we evaluated the protein delivery system LENA. We have shown that a transcription factor. Oct3/4 is successfully delivered to human cells via LENA. However, we found that the system have a room to improve because the biological function of Oct3/4 is detected weakly. We designed the second generation LENA to achieve the goal of this study.

Free Research Field

分子細胞生物学