Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24370057
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Rikkyo University
• Principal Investigator: GOTO Satoshi 立教大学, 理学部, 教授 (60280575)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 自然免疫 / 糖鎖 / ガラクトース

Outline of Final Research Achievements

The innate immune system is the first line of defense against invading pathogens. Activation of the innate immune response by infection and suppression during steady state are stringently controlled to eliminate pathogens and prevent inflammation. We found that host glycosylation plays an important role in the activation of immune responses and in maintaining innate immune homeostasis. In the steady state, a high amount of galactose-containing glycan suppresses undesirable activation of the immune response; however, activation of immune responses leads to reduced levels of galactose-containing glycan, which is needed for raising immune responses to an adequate level. Our finding suggests a novel mechanism for the regulation of innate immune quiescence and activation via changes in glycosylation status.

Free Research Field

糖鎖生物学