2014 Fiscal Year Final Research Report
Study on the regulation of immune responses by a novel IL-6/IL-12 family cytokine
| Project/Area Number |
24370058
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | EBI3 / IL-27 / p19 / IL-23R |
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| Outline of Final Research Achievements |
In the present study, we found that activated CD4+ T cells secreted p19 and EBI3, and that forced expression of them in cultured cells showed association of them. Moreover, injection of expression vector of EBI3/p19 into mice augmented IL-17 production, and transgenic mice of EBI3/p19 showed increased resistance to the development of autoimmune hepatitis possibly due to enhanced production of IL-22. Taken together, these results suggested that EBI3/p19 may be a novel functional heterodimeric molecule.
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| Free Research Field |
免疫学
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