2014 Fiscal Year Final Research Report
Elucidation of coordination between HP1 and polycomb complex for function of heterochromatin
Project/Area Number |
24370071
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Molecular biology
|
Research Institution | Hokkaido University |
Principal Investigator |
OBUSE Chikashi 北海道大学, 先端生命科学研究科(研究院), 教授 (00273855)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | ヘテロクロマチン / HP1 / ポリコーム複合体 |
Outline of Final Research Achievements |
Combining robust and flexible feature of heterochromatin is one of most important characteristics of "Epigenetics". To give the both features to heterochromatin, the relationships between constitutive heterochromatin based on H3K9me3-HP1 (heterochromatin protein 1) and facultative heterochromatin based on H3K27me3-PRC2 (polycomb repressive complex 2) will be responsible for the mechanism. This study revealed that HP1 associates with PRC2 through a histone H3K9 methyltransferase. These molecular links will contribute to understand the mechanism for robustness and flexibility of heterochromatin.
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Free Research Field |
分子細胞生物学
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