2014 Fiscal Year Final Research Report
Exploring the gut microbiota-derived immunomodulation factors
Project/Area Number |
24380072
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Keio University |
Principal Investigator |
FUKUDA Shinji 慶應義塾大学, 政策・メディア研究科, 准教授 (80435677)
|
Co-Investigator(Kenkyū-buntansha) |
HASE Koji 慶應義塾大学, 薬学部, 教授 (20359714)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | メタボロミクス / 統合オミクス / 腸内細菌 / 腸内代謝産物 / 短鎖脂肪酸 / 酪酸 / 炎症 / 制御性T細胞 |
Outline of Final Research Achievements |
Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. However, the molecular mechanisms by which commensal microbes induce colonic Treg cells have been unclear. We show that a large bowel microbial fermentation product, butyrate, induces the differentiation of colonic Treg cells in mice. An integrated omics approach identified gut microbiota-derived butyrate epigenetically induced the differentiation of Treg cells in vitro and in vivo, and ameliorated the development of colitis in mice. Our findings provide new insight into the mechanisms by which host–microbe interactions establish immunological homeostasis in the gut.
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Free Research Field |
腸内環境システム学
|