Integrated control to improve animal performance under environmental stress conditions: interactions between oxidative stress and metabolic and immunological responses

2014 Fiscal Year Final Research Report

• Project/Area Number: 24380147
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Tohoku University
• Principal Investigator: TOYOMIZU Masaaki 東北大学, (連合)農学研究科(研究院), 教授 (80180199)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Kazuaki 山形県立米沢栄養大学, 健康栄養学科, 教授 (80183440) ; OHTSU Haruhiko (独)農業, 食品産業技術総合研究機構・畜産草地研究所, 主任研究員 (40455316) ; KIKUSATO Motoi 東北大学, 農学研究科, 助教 (90613042)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 暑熱ストレス / 活性酸素種 / タンパク質分解速度 / サイトカイン / ミトコンドリア

Outline of Final Research Achievements

The present study was conducted to investigate the effect of heat stress (HS) and endotoxin stress on redox and metabolic states of broiler chickens. HS induced oxidative stress in skeletal muscle and liver. The anti-oxidant responses in the muscle were observed, but not in the liver. The treatments of birds with lipopolysaccharide did not induce oxidative damages to those tissues, while expression of inflammatory cytokines was enhanced. Then, electrolyzed reduced water and organic selenium were given HS-birds to aim at alleviating the oxidative stress and growth retardation. As results, oxidative stress was basically restored to normal values, whereas the growth in HS conditions was not improved by both treatments. Taken together, these findings suggest that not only regulation of oxidative stress but also optimization of other physiological alteration such as intestinal microbiota may be required in order to suppress the growth retardation due to HS conditions.

Free Research Field

動物生産科学、家禽科学、栄養生化学、代謝・生理学