Studies on the regulatory mechanisms of prolactin secretion by salsolinol in ruminants

2014 Fiscal Year Final Research Report

• Project/Area Number: 24380149
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied animal science
• Research Institution: Iwate University
• Principal Investigator: HASHIZUME Tsutomu 岩手大学, 農学部, 教授 (60124533)
• Research Collaborator: GYÖRGY Miklos Nagy Department of Human Morphology Semmelweis University, Hungary, 教授 ; FERENC Fülöp Institute of Pharmaceutical Chemistry University of Szeged, Hungary, 教授
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: サルソリノール / プロラクチン / ドーパミン / メラトニン / L-dopa / レセルピン / ヤギ / 反芻家畜

Outline of Final Research Achievements

Salsolinol(SAL), a dopamine (DA)-derived compound, is a putative endogenous prolactin (PRL)-releasing factor in ruminants. The aim of the present study was to clarify the secretory mechanisms of PRL by SAL in ruminants. Daily oral administrations of melatonin (MEL) under a long photoperiod reduced the PRL-releasing response to SAL in goats. The treatments with augmentation of central DA using carbidopa and L-dopa blunted SAL-induced PRL release in goats, regardless of the photoperiod. The treatments with depletion of central DA using reserpine modulated SAL-induced PRL release in goats. The present study demonstrated that hypothalamic MEL and DA are involved in the secretory mechanisms of PRL by SAL in goats. These results provide further evidence that SAL is involved in the regulatory processes of PRL secretion in ruminants.

Free Research Field

農学