2014 Fiscal Year Final Research Report
Development of aerobic alcohol oxidation systems based on nitroxyl radical-Cu catalysis
Project/Area Number |
24390001
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 空気酸化 / アルコール酸化 / 酸化触媒 / 銅ニトロキシド / 不斉酸化 / 化学選択性 |
Outline of Final Research Achievements |
We have successfully developed the highly chemoslective aerobic alcohol oxidation using nitroxyl radical-copper catalysis that realize an efficient transformation of an unprotected amino-alcohol into the corresponding amino-carabonyl compound. We have identified the optimum combination of nitroxyl radical, copper salt, and solution concentration dependent on the type of substrate. Useful information of the catalyst structure-enantioselectivity relationship has been obtained, which will lead the development of an enantioselective aerobic oxidation system.
|
Free Research Field |
化学系薬学
|