Improvement of tumor-targeting therapy with nanocarrier system by changing the tumor microenvironment.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390010
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: The University of Tokushima
• Principal Investigator: ISHIDA Tatsuhiro 徳島大学, ヘルスバイオサイエンス研究部, 教授 (50325271)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ドラッグデリバリー / リポソーム / がん治療 / がん微小環境

Outline of Final Research Achievements

Efficient systemic delivery　of anticancer drug to tumor tissue is a current critical challenge. Several studies have demonstrated that nanoparticles enhance the systemic delivery of anticancer drug to tumor via EPR effect. However, the disordered tumor microenvironment still poses a potential impediment with respect to the efficient delivery. Metronomic chemotherapy successfully improved the accumulation of PEG-coated liposome in solid tumor and improved therapeutic efficacy of oxaliplatin (l-OHP) encapsulated in the liposome. We also showed that repeated injection of l-OHP containing PEGylated liposome enhanced the accumulation of subsequently injected liposome and improved their therapeutic effect compared to the treatment with longer intervals between doses. The methodology (regimen) we proposed in this study may be applicable for clinical setting.

Free Research Field

薬剤学