Regulatory mechanisms of redox signal transduction mediated by endogenous electrophiles

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390082
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kumamoto University (2012, 2014); Tohoku University (2013)
• Principal Investigator: SAWA Tomohiro 熊本大学, 生命科学研究部, 教授 (30284756)
• Co-Investigator(Kenkyū-buntansha): AKAIKE Takaaki 東北大学, 大学院医学系研究科, 教授 (20231798) ; YOSHITAKE Jun 国立長寿医療研究センター, 研究院 (70414349)
• Co-Investigator(Renkei-kenkyūsha): KUMAGAI Yoshito 筑波大学, 大学院人間総合科学研究科, 教授 (00250100)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 活性酸素 / 酸化ストレス / シグナル伝達 / レドックス / 親電子

Outline of Final Research Achievements

This study identified the endogenous formation of cysteine persulfide species that brings additional sulfur atom to cysteine thiol. It is noteworthy that cysteine persulfide species are capable of metabolizing reactive oxygen species and their second messenger molecules such as 8-nitro-cGMP. Further study is warranted to clarify regulatory mechanisms of cycteine persulfide species formation as well as their biological functions.

Free Research Field

医歯薬学