2014 Fiscal Year Final Research Report
Regulation of gastric cancer development by mucin-type glycans
Project/Area Number |
24390086
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Shinshu University |
Principal Investigator |
NAKAYAMA Jun 信州大学, 学術研究院医学系, 教授 (10221459)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 胃癌 / 幽門腺型腺腫 / 慢性萎縮性胃炎 / バレット食道 / 遺伝子改変マウス / 糖鎖 / 腺粘液 / 病理診断 |
Outline of Final Research Achievements |
Gastric gland mucins contain terminal α1,4-linked N-acetylglucosamine (αGlcNAc). This glycan prevents gastric cancer development by exhibiting antimicrobial activity against H. pylori as well as suppressing chronic inflammation. In this study, we analyzed expression of αGlcNAc and its pathological significance on human gastric diseases including gastric adenocarcinoma, pyloric gland adenoma, and chronic atrophic gastritis as well as Barrett's esophagus. Our results indicate that reduction or loss of αGlcNAc are associated with malignant potential of gastric differentiated-type adenocarcinoma and pyloric gland adenoma. We also showed that reduced αGlcNAc expression in chronic atrophic gastritis and Barrett's esophagus was a possible risk factor to develop gastric differentiated-type adenocarcinoma and Barrett's adenocarcinoma, respectively. In parallel, we generated new genetically engineered mice useful to study the regulatory roles of αGlcNAc in tumorigenesis of gastric cancer.
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Free Research Field |
人体病理学、糖鎖生物学、組織細胞化学
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