2014 Fiscal Year Final Research Report
Analysis of viral infection and innate immune response using humanized mice
| Project/Area Number |
24390112
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ヒト化マウス / ウイルス制御因子 / HIV / tetherin / APOBEC3 |
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| Outline of Final Research Achievements |
Using a human hematopoietic stem cell-transplanted humanized mouse model, we found a series of HIV-1 infection mechanisms. Vpu contributes to efficient spread of HIV-1 in vivo. Vpu concomitantly downregulates tetherin and CD4 from the surface of infected cells. Vpr induces depletion of CCR5+ FOXP3+ CD4+ regulatory T cells （Treg） for enhancing viremia of CCR5-tropic HIV-1. APOBEC3F and APOBEC3G fundamentally work as restriction factors against HIV-1 in vivo, but at the same time, that APOBEC3F are capable of promoting viral diversification and evolution in vivo.
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| Free Research Field |
ウイルス学
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