High throughput screening of chemical library for antiviral compounds for hepatitis viruses

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hokkaido University
• Principal Investigator: SAKAMOTO Naoya 北海道大学, 医学(系)研究科(研究院), 教授 (10334418)
• Co-Investigator(Kenkyū-buntansha): ASAHINA Yasuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教員 (00422692)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肝炎ウイルス

Outline of Final Research Achievements

We have conducted a high throughput screening of chemical library for antiviral compounds against hepatitis C and hepatitis B viruses and acquired the following results. 1. GPx8, a host protein, was cleaved by HCV-NS3/4A serene protease and enhanced viral replication in the host cells. 2. L-carnitine suppressed HCV viral assembly by targeting formation of cellular lipid vesicles. With the above results, it is possible that we can constitute novel antiviral therapeutics against hepatitis viruses.

Free Research Field

消化器内科学