Development of prophylaxis and therapy system for metabolic stmdorome by regulation of AIM function

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390196
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: ARAI Satoko 東京大学, 医学(系)研究科(研究院), 准教授 (60422276)
• Co-Investigator(Renkei-kenkyūsha): MIYAZAKI Toru 東京大学, 大学院医学系研究科, 教授 (30396270)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: AIM / 生活習慣病 / HCC

Outline of Final Research Achievements

Since AIM (apoptosis inhibitor of macrophage), a secreted protein produced from macrophages, has been shown to be involved in metabolic syndromes such as obesity, insulin resistance and atherosclerosis, regulation of both function and amount of AIM in body can be effective to prevent or control the AIM-related diseases. In this study, we investigated mechanism and materials for regulation of function and level of AIM. In addition, we presented that AIM is involved in the obesity-derived diseases such like auto-reactive antibody production and steatosis-derived hepatocellular carcinoma. Furthermore, we performed a large-scale analysis for blood AIM concentration in human including healthy individuals and patients with liver diseases, and demonstrated that AIM can be applied for the diagnosis of HCC in humans.

Free Research Field

疾患生命科学